Zhi-Song Xing1, Guang Zhu2, Yu-Lun Yang1, Guang-Qiang Feng1, Guang-Cheng Ding3. 1. Department of Thoracic Surgery, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 2. Department of Science and Education, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 3. Department of Radiotherapy, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: guangchengding@163.com.
Abstract
OBJECTIVE: To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia. METHODS: Related studies of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed, Embase Library, SPRINGER, CNKI and CSSCI. RESULTS: According to the entry criteria, there were 8 case-control studies in the assessing system and there were 6 321 study cases, including 3 215 patients with lung cancer and 3 106 cases without cancers. Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03 (95%CI: 0.89-1.20) (P>0.05). CONCLUSIONS: XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia. Allele 241Met did not increase the risk of lung cancer.
OBJECTIVE: To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia. METHODS: Related studies of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed, Embase Library, SPRINGER, CNKI and CSSCI. RESULTS: According to the entry criteria, there were 8 case-control studies in the assessing system and there were 6 321 study cases, including 3 215 patients with lung cancer and 3 106 cases without cancers. Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03 (95%CI: 0.89-1.20) (P>0.05). CONCLUSIONS:XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia. Allele 241Met did not increase the risk of lung cancer.
Authors: Andreea Catana; Monica Pop; Dragos Horea Marginean; Ioana Cristina Blaga; Mihai Dumitru Porojan; Radu Anghel Popp; Ioan Victor Pop Journal: Clujul Med Date: 2016-01-15