Xin Zhou1, Xiaomin Ou1, Tingting Xu1, Xiaosheng Wang1, Chunying Shen1, Jianhui Ding2, Chaosu Hu3. 1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. 2. Department of Diagnostic Radiology, Fudan University Shanghai Cancer Center, Shanghai, China. 3. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. Electronic address: hucsu62@yahoo.com.
Abstract
PURPOSE: To determine dosimetric risk factors for the occurrence of temporal lobe necrosis (TLN) among nasopharyngeal carcinoma (NPC) patients treated with intensity modulated radiation therapy (IMRT) and to investigate the impact of dose-volume histogram (DVH) parameters on the volume of TLN lesions (V-N). METHODS AND MATERIALS: Forty-three NPC patients who had developed TLN following IMRT and 43 control subjects free of TLN were retrospectively assessed. DVH parameters included maximum dose (Dmax), minimum dose (Dmin), mean dose (Dmean), absolute volumes receiving specific dose (Vds) from 20 to 76 Gy (V20-V76), and doses covering certain volumes (Dvs) from 0.25 to 6.0 cm(3) (D0.25-D6.0). V-Ns were quantified with axial magnetic resonance images. RESULTS: DVH parameters were ubiquitously higher in temporal lobes with necrosis than in healthy temporal lobes. Increased Vds and Dvs were significantly associated with higher risk of TLN occurrence (P<.05). In particular, Vds at a dose of ≥70 Gy were found with the highest odds ratios. A common increasing trend was detected between V-N and DVH parameters through trend tests (P for trend of <.05). Linear regression analysis showed that V45 had the strongest predictive power for V-N (adjusted R(2) = 0.305, P<.0001). V45 of <15.1 cm(3) was relatively safe as the dose constraint for preventing large TLN lesions with V-N of >5 cm(3). CONCLUSIONS: Dosimetric parameters are significantly associated with TLN occurrence and the extent of temporal lobe injury. To better manage TLN, it would be important to avoid both focal high dose and moderate dose delivered to a large area in TLs.
PURPOSE: To determine dosimetric risk factors for the occurrence of temporal lobe necrosis (TLN) among nasopharyngeal carcinoma (NPC) patients treated with intensity modulated radiation therapy (IMRT) and to investigate the impact of dose-volume histogram (DVH) parameters on the volume of TLN lesions (V-N). METHODS AND MATERIALS: Forty-three NPCpatients who had developed TLN following IMRT and 43 control subjects free of TLN were retrospectively assessed. DVH parameters included maximum dose (Dmax), minimum dose (Dmin), mean dose (Dmean), absolute volumes receiving specific dose (Vds) from 20 to 76 Gy (V20-V76), and doses covering certain volumes (Dvs) from 0.25 to 6.0 cm(3) (D0.25-D6.0). V-Ns were quantified with axial magnetic resonance images. RESULTS: DVH parameters were ubiquitously higher in temporal lobes with necrosis than in healthy temporal lobes. Increased Vds and Dvs were significantly associated with higher risk of TLN occurrence (P<.05). In particular, Vds at a dose of ≥70 Gy were found with the highest odds ratios. A common increasing trend was detected between V-N and DVH parameters through trend tests (P for trend of <.05). Linear regression analysis showed that V45 had the strongest predictive power for V-N (adjusted R(2) = 0.305, P<.0001). V45 of <15.1 cm(3) was relatively safe as the dose constraint for preventing large TLN lesions with V-N of >5 cm(3). CONCLUSIONS: Dosimetric parameters are significantly associated with TLN occurrence and the extent of temporal lobe injury. To better manage TLN, it would be important to avoid both focal high dose and moderate dose delivered to a large area in TLs.
Authors: Christopher R Peeler; Dragan Mirkovic; Uwe Titt; Pierre Blanchard; Jillian R Gunther; Anita Mahajan; Radhe Mohan; David R Grosshans Journal: Radiother Oncol Date: 2016-11-16 Impact factor: 6.280
Authors: Emma Holliday; Onita Bhattasali; Merrill S Kies; Ehab Hanna; Adam S Garden; David I Rosenthal; William H Morrison; G Brandon Gunn; Jack Phan; X Ronald Zhu; Xiaodong Zhang; Steven J Frank Journal: Int J Part Ther Date: 2016-03-24
Authors: Sarin Kitpanit; Anna Lee; Ken L Pitter; Dan Fan; James C H Chow; Brian Neal; Zhiqiang Han; Pamela Fox; Kevin Sine; Dennis Mah; Lara A Dunn; Eric J Sherman; Loren Michel; Ian Ganly; Richard J Wong; Jay O Boyle; Marc A Cohen; Bhuvanesh Singh; Cameron W Brennan; Igor T Gavrilovic; Vaios Hatzoglou; Bernard O'Malley; Kaveh Zakeri; Yao Yu; Linda Chen; Daphna Y Gelblum; Jung Julie Kang; Sean M McBride; Chiaojung J Tsai; Nadeem Riaz; Nancy Y Lee Journal: Int J Part Ther Date: 2020-05-28