Literature DB >> 2506536

Reduced growth hormone releasing factor (GHRF)-like immunoreactivity and GHRF gene expression in the hypothalamus of aged rats.

V DeGennaro Colonna1, M Zoli, D Cocchi, A Maggi, P Marrama, L F Agnati, E E Müller.   

Abstract

Growth hormone releasing factor-like immunoreactivity (GHRF-LI) and GHRF mRNA levels were evaluated in the hypothalamus of aged (24 months) and young (3 months) rats by semiquantitative immunocytochemistry and slot blot hybridization technique, respectively. Simultaneous detection of reduced GHRF-LI and GHRF mRNA levels in aged rats as compared to young counterparts demonstrates the existence in aged rats of an impaired function of GHRF-producing neurons.

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Year:  1989        PMID： 2506536     DOI： 10.1016/0196-9781(89)90164-2

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  5 in total

Review 1.  Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans.

Authors:  J D Veldhuis; A Iranmanesh; A Weltman
Journal:  Endocrine       Date:  1997-08       Impact factor: 3.633

2.  Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging.

Authors:  E Arvat; G P Ceda; L Di Vito; J Ramunni; L Gianotti; F Broglio; R Deghenghi; E Ghigo
Journal:  Pituitary       Date:  1998-04       Impact factor: 4.107

3.  Dietary restriction maintains the basal rate of somatotrope renewal in later life in male rats.

Authors:  I Shimokawa; M Tomita; Y Higami; T Okimoto; T Kawahara; T Ikeda
Journal:  Age (Omaha)       Date:  1997-07

4.  Arginine enhances the growth hormone-releasing activity of a synthetic hexapeptide (GHRP-6) in elderly but not in young subjects after oral administration.

Authors:  E Ghigo; E Arvat; G Rizzi; J Bellone; M Nicolosi; G M Boffano; M Mucci; M F Boghen; F Camanni
Journal:  J Endocrinol Invest       Date:  1994-03       Impact factor: 4.256

5.  Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects.

Authors:  E Ghigo; G P Ceda; R Valcavi; S Goffi; M Zini; M Mucci; G Valenti; D Cocchi; E E Müller; F Camanni
Journal:  J Endocrinol Invest       Date:  1994-02       Impact factor: 4.256
  5 in total

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