Literature DB >> 2506505

Opioid involvement in TRH-induced antinociception in the rat following intracerebral administration.

V Reny-Palasse1, C Monier, R Rips.   

Abstract

Thyrotropin-releasing hormone (TRH) has an antinociceptive action in the rat. Antinociception was observed using a thermal stimulus (tail-flick test) after TRH administration into lateral ventricle, nucleus raphe magnus, nucleus reticularis paragigantocellularis and amygdaloid nuclei. This effect was short-lived since it was completely abolished 60 min after intracerebroventricular administration. TRH may interact with the opioid systems as its antinociceptive effect was blocked by pretreatment with naloxone.

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Year:  1989        PMID： 2506505     DOI： 10.1016/0304-3959(89)90238-8

Source DB:  PubMed          Journal:  Pain        ISSN： 0304-3959            Impact factor:   6.961


  3 in total

1.  The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems.

Authors:  M Tanabe; Y Tokuda; K Takasu; K Ono; M Honda; H Ono
Journal:  Br J Pharmacol       Date:  2007-01-15       Impact factor: 8.739

2.  Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats.

Authors:  James D Boghosian; Anita Luethy; Joseph F Cotten
Journal:  J Pharmacol Exp Ther       Date:  2018-04-19       Impact factor: 4.030

Review 3.  Interactive Mechanisms of Supraspinal Sites of Opioid Analgesic Action: A Festschrift to Dr. Gavril W. Pasternak.

Authors:  Grace C Rossi; Richard J Bodnar
Journal:  Cell Mol Neurobiol       Date:  2020-09-24       Impact factor: 5.046
  3 in total

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