Literature DB >> 2506496

Decreased peroxidative potential in rat brain microsomal fractions during ageing.

T P Devasagayam1.   

Abstract

Rough and smooth microsomes of brain in senescent rats showed less sensitivity to ascorbate-, NADPH- and cumene hydroperoxide-induced peroxidative damage compared with those of young adults. The observed decrease in peroxidative potential in senescent rats seemed to be due to decrease in the substrate for peroxidation in the form of phospholipids and increase in the level of antioxidants such as reduced glutathione and superoxide dismutase.

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Year:  1989        PMID: 2506496     DOI: 10.1016/0304-3940(89)90491-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  2 in total

1.  Vanillin as an antioxidant in rat liver mitochondria: inhibition of protein oxidation and lipid peroxidation induced by photosensitization.

Authors:  J P Kamat; A Ghosh; T P Devasagayam
Journal:  Mol Cell Biochem       Date:  2000-06       Impact factor: 3.396

2.  Age-dependent accumulation of phosphatidylcholine hydroperoxide in the brain and liver of the rat.

Authors:  T Miyazawa; T Suzuki; K Fujimoto
Journal:  Lipids       Date:  1993-09       Impact factor: 1.880

  2 in total

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