Akihiko Machino1, Yoshihiko Kunisato2, Tomoya Matsumoto3, Shinpei Yoshimura4, Kazutaka Ueda5, Yosuke Yamawaki6, Go Okada3, Yasumasa Okamoto3, Shigeto Yamawaki7. 1. Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. 2. Graduate School of the Humanities, Sensyu University, 2-1-1 Higashi Mita, Tama-ku, Kanagawa, Kawasaki 214-8580, Japan. 3. Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), 4-1-8 Honmachi, Kawaguchi, Saitama 332-0012, Japan. 4. Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan; Faculty of Psychology, Otemon Gakuin University, 2-1-15 Nishiai, Ibaraki, Osaka 567-8502, Japan. 5. Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. 6. Laboratory of Molecular and Cellular Pharmacology, Faculty of Pharmatheutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan. 7. Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), 4-1-8 Honmachi, Kawaguchi, Saitama 332-0012, Japan. Electronic address: yamawaki@hiroshima-u.ac.jp.
Abstract
BACKGROUND: A recent meta-analysis of many magnetic resonance imaging (MRI) studies has identified brain regions with gray matter (GM) abnormalities in patients with major depressive disorder (MDD). A few studies addressing GM abnormalities in patients with treatment-resistant depression (TRD) have yielded inconsistent results. Moreover, although TRD patients tend to exhibit ruminative thoughts, it remains unclear whether rumination is related to GM abnormalities in such patients or not. METHODS: We conducted structural MRI scans and voxel-based morphometry (VBM) to identify GM differences among 29 TRD patients and 29 healthy age-matched and sex-matched controls. A response style questionnaire was used to assess the respective degrees of rumination in TRD patients. Structural correlates of rumination were examined. RESULTS: TRD patients showed several regions with smaller GM volume than in healthy subjects: the left dorsal anterior cingulate cortex (ACC), right ventral ACC, right superior frontal gyrus, right cerebellum (Crus I), and cerebellar vermis. GM volumes in these regions did not correlate to rumination. However, whole-brain analysis revealed that rumination was positively correlated with the GM volume in the right superior temporal gyrus in TRD patients. LIMITATIONS: Structural correlates of rumination were examined only in TRD patients. CONCLUSIONS: Our data provide additional evidence supporting the hypothesis that TRD patients show GM abnormalities compared with healthy subjects. Furthermore, this report is the first to describe a study identifying brain regions for which the GM volume is correlated with rumination in TRD patients. These results improve our understanding of the anatomical characteristics of TRD.
BACKGROUND: A recent meta-analysis of many magnetic resonance imaging (MRI) studies has identified brain regions with gray matter (GM) abnormalities in patients with major depressive disorder (MDD). A few studies addressing GM abnormalities in patients with treatment-resistant depression (TRD) have yielded inconsistent results. Moreover, although TRD patients tend to exhibit ruminative thoughts, it remains unclear whether rumination is related to GM abnormalities in such patients or not. METHODS: We conducted structural MRI scans and voxel-based morphometry (VBM) to identify GM differences among 29 TRD patients and 29 healthy age-matched and sex-matched controls. A response style questionnaire was used to assess the respective degrees of rumination in TRD patients. Structural correlates of rumination were examined. RESULTS: TRD patients showed several regions with smaller GM volume than in healthy subjects: the left dorsal anterior cingulate cortex (ACC), right ventral ACC, right superior frontal gyrus, right cerebellum (Crus I), and cerebellar vermis. GM volumes in these regions did not correlate to rumination. However, whole-brain analysis revealed that rumination was positively correlated with the GM volume in the right superior temporal gyrus in TRD patients. LIMITATIONS: Structural correlates of rumination were examined only in TRD patients. CONCLUSIONS: Our data provide additional evidence supporting the hypothesis that TRD patients show GM abnormalities compared with healthy subjects. Furthermore, this report is the first to describe a study identifying brain regions for which the GM volume is correlated with rumination in TRD patients. These results improve our understanding of the anatomical characteristics of TRD.
Authors: Marc S Lener; Prantik Kundu; Edmund Wong; Kaitlin E Dewilde; Cheuk Y Tang; Priti Balchandani; James W Murrough Journal: J Affect Disord Date: 2015-10-30 Impact factor: 4.839
Authors: Nora Eszlari; Andras Millinghoffer; Peter Petschner; Xenia Gonda; Daniel Baksa; Attila J Pulay; János M Réthelyi; Gerome Breen; John Francis William Deakin; Peter Antal; Gyorgy Bagdy; Gabriella Juhasz Journal: Transl Psychiatry Date: 2019-03-18 Impact factor: 6.222