Literature DB >> 2506442

Calcium phosphate-mediated transfection alters metallothionein gene expression in response to Cd2+ and Zn2+.

R Foster1, P E Olsson, L Gedamu.   

Abstract

The level of expression of a transfected metallothionein (MT)-IGcat fusion gene in response to cadmium differed from that of the endogenous MT-IG gene. Atomic absorption analysis indicated that the total cellular content of cadmium and zinc increased upon calcium phosphate-mediated transfection. Thus, changes in the influx/efflux of metals may regulate the level of MT gene expression.

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Year:  1989        PMID： 2506442      PMCID： PMC362482          DOI： 10.1128/mcb.9.9.4105-4108.1989

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  17 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  Structure and expression of two human metallothionein-I isoform genes and a related pseudogene.

Authors:  C J Schmidt; M F Jubier; D H Hamer
Journal:  J Biol Chem       Date:  1985-06-25       Impact factor: 5.157

Review 3.  Metallothionein.

Authors:  D H Hamer
Journal:  Annu Rev Biochem       Date:  1986       Impact factor: 23.643

Review 4.  Biological applications of ionophores.

Authors:  B C Pressman
Journal:  Annu Rev Biochem       Date:  1976       Impact factor: 23.643

5.  Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids.

Authors:  U Varshney; N Jahroudi; R Foster; L Gedamu
Journal:  Mol Cell Biol       Date:  1986-01       Impact factor: 4.272

6.  Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids.

Authors:  R I Richards; A Heguy; M Karin
Journal:  Cell       Date:  1984-05       Impact factor: 41.582

7.  Cell specificity and an effect of ras on human metallothionein gene expression.

Authors:  C J Schmidt; D H Hamer
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

8.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

9.  Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene.

Authors:  M Karin; R I Richards
Journal:  Nature       Date:  1982-10-28       Impact factor: 49.962

10.  Structure of mammalian metallothionein.

Authors:  J H Kägi; M Vasák; K Lerch; D E Gilg; P Hunziker; W R Bernhard; M Good
Journal:  Environ Health Perspect       Date:  1984-03       Impact factor: 9.031
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  2 in total

1.  Host range specificity of polyomavirus EC mutants in mouse embryonal carcinoma and embryonal stem cells and preimplantation embryos.

Authors:  F Mélin; R Kemler; C Kress; H Pinon; D Blangy
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

2.  Feedback regulation of collagen gene expression: a Trojan horse approach.

Authors:  L Fouser; E H Sage; J Clark; P Bornstein
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205
  2 in total

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