S Lambert1, P Santulli2, S Chouzenoux3, L Marcellin4, B Borghese4, D de Ziegler5, F Batteux3, C Chapron2. 1. Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. Electronic address: lambertsixtine@gmail.com. 2. Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Laboratoire d'immunologie, EA 1833, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 75679 Paris, France; Inserm, unité de recherche U1016, faculté de médecine, institut Cochin, CNRS (UMR8104), université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. 3. Laboratoire d'immunologie, EA 1833, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 75679 Paris, France. 4. Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm, unité de recherche U1016, faculté de médecine, institut Cochin, CNRS (UMR8104), université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. 5. Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
Abstract
OBJECTIVES: To assess interleukin-1β (IL-1β) and its inhibitory soluble interleukin-1 receptor type II (IL-1sRII) levels into the serum of patients with various forms of endometriosis and normal women, and investigate the correlation with disease activity. PATIENTS AND METHODS: In this prospective laboratory study (2005-2010), 510 women with histologically proven endometriosis and 93 endometriosis-free controls have been enrolled. Laparoscopic complete exploration of the abdominopelvic cavity and blood samples have been performed in each patient. For each serum, IL-1β and IL-1sRII have been evaluated using Elisa. RESULTS: IL-1β and IL-1sRII have been respectively detectable in 64% and 54.6% of serum samples from all 603 women studied. IL-1β was higher in women with deep infiltrating endometriosis (DIE) (mean 10.0pg/mL [0.005-416.2]) than in endometriosis-free women (mean 0.5pg/mL [0.01-1.7], P<0.01) or in women with superficial endometriosis (SUP) (mean 0.6pg/mL [0.1-2.9], P<0.01). Also, IL-1sRII was higher in DIE (mean 236.7pg/mL [0.9-6975]) than in the witness group (mean 85.0pg/mL [1-235.2], P<0.05) or in SUP (mean 85.1pg/mL [0.6-302], P<0.01). CONCLUSION: This study highlights both a marked significant increase in serum IL-1β and IL-1sRII levels in DIE compared to SUP and normal women and suggests that a defect in the control of IL-1 can impact the pathophysiology of endometriosis.
OBJECTIVES: To assess interleukin-1β (IL-1β) and its inhibitory soluble interleukin-1 receptor type II (IL-1sRII) levels into the serum of patients with various forms of endometriosis and normal women, and investigate the correlation with disease activity. PATIENTS AND METHODS: In this prospective laboratory study (2005-2010), 510 women with histologically proven endometriosis and 93 endometriosis-free controls have been enrolled. Laparoscopic complete exploration of the abdominopelvic cavity and blood samples have been performed in each patient. For each serum, IL-1β and IL-1sRII have been evaluated using Elisa. RESULTS: IL-1β and IL-1sRII have been respectively detectable in 64% and 54.6% of serum samples from all 603 women studied. IL-1β was higher in women with deep infiltrating endometriosis (DIE) (mean 10.0pg/mL [0.005-416.2]) than in endometriosis-freewomen (mean 0.5pg/mL [0.01-1.7], P<0.01) or in women with superficial endometriosis (SUP) (mean 0.6pg/mL [0.1-2.9], P<0.01). Also, IL-1sRII was higher in DIE (mean 236.7pg/mL [0.9-6975]) than in the witness group (mean 85.0pg/mL [1-235.2], P<0.05) or in SUP (mean 85.1pg/mL [0.6-302], P<0.01). CONCLUSION: This study highlights both a marked significant increase in serum IL-1β and IL-1sRII levels in DIE compared to SUP and normal women and suggests that a defect in the control of IL-1 can impact the pathophysiology of endometriosis.
Authors: Vicki Nisenblat; Patrick M M Bossuyt; Rabia Shaikh; Cindy Farquhar; Vanessa Jordan; Carola S Scheffers; Ben Willem J Mol; Neil Johnson; M Louise Hull Journal: Cochrane Database Syst Rev Date: 2016-05-01
Authors: Andrei M Malutan; Tudor Drugan; Nicolae Costin; Razvan Ciortea; Carmen Bucuri; Maria P Rada; Dan Mihu Journal: Cent Eur J Immunol Date: 2015-04-22 Impact factor: 2.085