Ligia Maria Suppo de Souza Rugolo1, Maria Regina Bentlin2, Marisa Mussi-Pinhata3, Maria Fernanda Branco de Almeida4, José Maria de Andrade Lopes5, Sergio Tadeu Martins Marba6, Humberto Holmer Fiori7, Renato Soibelmann Procianoy8, Clea Rodrigues Leone9. 1. Department of Pediatrics, Botucatu School of Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil ligiasr@fmb.unesp.br. 2. Department of Pediatrics, Botucatu School of Medicine, Sao Paulo State University-UNESP, Botucatu, SP, Brazil. 3. Department of Pediatrics, University of São Paulo, Ribeirão Preto, SP, Brazil. 4. Division of Neonatal Medicine, Universidade Federal de São Paulo, SP, Brazil. 5. Neonatal Department, Fernandes Figueira Institute of Oswaldo Cruz Foundation, RJ, Brazil. 6. Department of Pediatrics, State University of Campinas, Campinas, SP, Brazil. 7. Department of Pediatrics, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil. 8. Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. 9. Department of Pediatrics, University of São Paulo, SP, Brazil.
Abstract
BACKGROUND: Late-onset sepsis (LOS) is an important cause of morbidity and mortality in very low birth weight (VLBW) infants. AIM: To determine the incidence, risk factors and etiology of LOS. METHODS: LOS was investigated in a multicenter prospective cohort of infants at eight public university neonatal intensive care units (NICUs). Inclusion criteria included inborn, 23-33 weeks of gestational age, 400-1499 g birth weight, who survived >3 days. RESULTS: Of 1507 infants, 357 (24%) had proven LOS and 345 (23%) had clinical LOS. Infants with LOS were more likely to die. The majority of infections (76%) were caused by Gram-positive organisms. Independent risk factors for proven LOS were use of central venous catheter and mechanical ventilation, age at the first feeding and number of days on parenteral nutrition and on mechanical ventilation. CONCLUSION: LOS incidence and mortality are high in Brazilian VLBW infants. Most risk factors are associated with routine practices at NICU.
BACKGROUND: Late-onset sepsis (LOS) is an important cause of morbidity and mortality in very low birth weight (VLBW) infants. AIM: To determine the incidence, risk factors and etiology of LOS. METHODS: LOS was investigated in a multicenter prospective cohort of infants at eight public university neonatal intensive care units (NICUs). Inclusion criteria included inborn, 23-33 weeks of gestational age, 400-1499 g birth weight, who survived >3 days. RESULTS: Of 1507 infants, 357 (24%) had proven LOS and 345 (23%) had clinical LOS. Infants with LOS were more likely to die. The majority of infections (76%) were caused by Gram-positive organisms. Independent risk factors for proven LOS were use of central venous catheter and mechanical ventilation, age at the first feeding and number of days on parenteral nutrition and on mechanical ventilation. CONCLUSION: LOS incidence and mortality are high in Brazilian VLBW infants. Most risk factors are associated with routine practices at NICU.
Authors: Ming Ying Gan; Wen Li Lee; Bei Jun Yap; Shu Ting Tammie Seethor; Rachel G Greenberg; Jen Heng Pek; Bobby Tan; Christoph Paul Vincent Hornik; Jan Hau Lee; Shu-Ling Chong Journal: Front Pediatr Date: 2022-06-03 Impact factor: 3.569
Authors: Johanes Edy Siswanto; Peter H Dijk; Arend F Bos; Rita S Sitorus; Asri C Adisasmita; Sudarto Ronoatmodjo; Pieter J J Sauer Journal: Health Sci Rep Date: 2021-01-18