| Literature DB >> 25063032 |
Youguo Ling1, Xiaojuan Zhang2, Yuanyuan Bai3, Ping Li3, Congwen Wei3, Ting Song3, Zirui Zheng3, Kai Guan3, Yanhong Zhang3, Buchang Zhang4, Xuedong Liu5, Runlin Z Ma2, Cheng Cao6, Hui Zhong7, Quanbin Xu8.
Abstract
The spindle assembly checkpoint kinase Mps1 is highly expressed in several types of cancers, but its cellular involvement in tumorigenesis is less defined. Herein, we confirm that Mps1 is overexpressed in colon cancer tissues. Further, we find that forced expression of Mps1 in the colon cancer cell line SW480 enables cells to become resistant to both Mps1 inhibition-induced checkpoint depletion and cell death. Overexpression of Mps1 also increases genome instability in tumor cells owing to a weakened spindle assembly checkpoint. Collectively, our findings suggest that high levels of Mps1 contribute to tumorigenesis by attenuating the spindle assembly checkpoint.Entities:
Keywords: Aneuploidy; Mps1; Overexpression; Spindle assembly checkpoint; Tumorigenesis
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Year: 2014 PMID： 25063032 DOI： 10.1016/j.bbrc.2014.07.071
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575