Literature DB >> 25062432

Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients.

Ting Wang1, Linden A Green, Samir K Gupta, Tohti Amet, Daniel J Byrd, Qigui Yu, Homer L Twigg, Matthias Clauss.   

Abstract

We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART.

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Year:  2014        PMID： 25062432      PMCID： PMC4313413          DOI： 10.1089/AID.2013.0250

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  21 in total

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Authors:  H W Kestler; D J Ringler; K Mori; D L Panicali; P K Sehgal; M D Daniel; R C Desrosiers
Journal:  Cell       Date:  1991-05-17       Impact factor: 41.582

2.  The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs.

Authors:  Ashutosh Chaudhry; Suman Ranjan Das; Amjad Hussain; Satyajit Mayor; Anna George; Vineeta Bal; Shahid Jameel; Satyajit Rath
Journal:  J Immunol       Date:  2005-10-01       Impact factor: 5.422

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Authors:  Chuang C Chiueh; Tsugunobu Andoh; P Boon Chock
Journal:  Toxicol Appl Pharmacol       Date:  2005-09-01       Impact factor: 4.219

4.  Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.

Authors:  J V Garcia; A D Miller
Journal:  Nature       Date:  1991-04-11       Impact factor: 49.962

5.  Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes.

Authors:  Christopher A Lundquist; Minoru Tobiume; Jing Zhou; Derya Unutmaz; Christopher Aiken
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

6.  Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.

Authors:  A Mangasarian; V Piguet; J K Wang; Y L Chen; D Trono
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

7.  CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.

Authors:  Xiaoduan Weng; Elena Priceputu; Pavel Chrobak; Johanne Poudrier; Denis G Kay; Zaher Hanna; Tak W Mak; Paul Jolicoeur
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

8.  Construction of single-chain antibodies that bind an overlapping epitope of HIV-1 Nef.

Authors:  A H Chang; J A Hoxie; S Cassol; M O'Shaughnessy; F Jirik
Journal:  FEBS Lett       Date:  1998-12-18       Impact factor: 4.124

9.  Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein.

Authors:  O Schwartz; V Maréchal; S Le Gall; F Lemonnier; J M Heard
Journal:  Nat Med       Date:  1996-03       Impact factor: 53.440

10.  Naive and memory T cells show distinct pathways of lymphocyte recirculation.

Authors:  C R Mackay; W L Marston; L Dudler
Journal:  J Exp Med       Date:  1990-03-01       Impact factor: 14.307
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  13 in total

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Authors:  A Sami Saribas; Kamel Khalili; Ilker Kudret Sariyer
Journal:  Cell Cycle       Date:  2015-07-15       Impact factor: 4.534

2.  Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes.

Authors:  Jaime Uhl; Shivalee Gujarathi; Abdul A Waheed; Ana Gordon; Eric O Freed; Karine Gousset
Journal:  J Cell Commun Signal       Date:  2018-11-15       Impact factor: 5.782

3.  Pharmacologic HIV-1 Nef blockade promotes CD8 T cell-mediated elimination of latently HIV-1-infected cells in vitro.

Authors:  Shariq Mujib; Aamir Saiyed; Saleh Fadel; Ardalan Bozorgzad; Nasra Aidarus; Feng Yun Yue; Erika Benko; Colin Kovacs; Lori A Emert-Sedlak; Thomas E Smithgall; Mario A Ostrowski
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Review 5.  Defective HIV-1 genomes and their potential impact on HIV pathogenesis.

Authors:  Jeffrey Kuniholm; Carolyn Coote; Andrew J Henderson
Journal:  Retrovirology       Date:  2022-06-28       Impact factor: 3.768

6.  HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy.

Authors:  Manish K Gupta; Rafal Kaminski; Brian Mullen; Jennifer Gordon; Tricia H Burdo; Joseph Y Cheung; Arthur M Feldman; Muniswamy Madesh; Kamel Khalili
Journal:  Sci Rep       Date:  2017-08-17       Impact factor: 4.379

7.  HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders.

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9.  Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV.

Authors:  Erik Ehinger; Yanal Ghosheh; Akula Bala Pramod; Juan Lin; David B Hanna; Karin Mueller; Christopher P Durant; Livia Baas; Qibin Qi; Tao Wang; Konrad Buscher; Kathryn Anastos; Jason M Lazar; Wendy J Mack; Phyllis C Tien; Mardge H Cohen; Igho Ofotokun; Stephen Gange; Sonya L Heath; Howard N Hodis; Russell P Tracy; Alan L Landay; Robert C Kaplan; Klaus Ley
Journal:  Cardiovasc Res       Date:  2021-03-21       Impact factor: 13.081

10.  Atherosclerosis in subjects newly diagnosed with human immunodeficiency virus infection.

Authors:  Tatiana V Kirichenko; Veronika A Myasoedova; Tatiana E Shimonova; Alexandra A Melnichenko; Dmitri Sviridov; Igor A Sobenin; Alexey I Mazus; Alexander N Orekhov; Michael I Bukrinsky
Journal:  Biosci Rep       Date:  2018-07-18       Impact factor: 3.840
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