| Literature DB >> 2506139 |
S B Fink1, M Finiasz, L Sterin-Borda, E Borda, M M de Bracco.
Abstract
The positive inotropic effect of cell-free supernatants from lectin-activated lymphocytes is lost by dialysis and can be partially restored by addition of arachidonic acid (AA). Interleukin-2 (IL-2) in the presence of AA could stimulate the response of the heart while the interferons (alpha-IFN or gamma-IFN) were ineffective. The activity of PHA-L-SN and that of IL-2 + AA was neutralized by anti-IL-2 MAb. These results suggest a key role for IL-2 in the stimulation of heart contractility by supernatants from activated lymphocytes.Entities:
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Year: 1989 PMID： 2506139 DOI： 10.1016/0192-0561(89)90082-9
Source DB: PubMed Journal: Int J Immunopharmacol ISSN： 0192-0561