Literature DB >> 25061

Formation of 3,N4-ethenocytidine moieties in RNA by vinyl chloride metabolities in vitro and in vivo.

R J Laib, H M Bolt.   

Abstract

Rats were exposed to [1,2-14C] vinyl chloride. Liver RNA was isolated, hydrolyzed, and the nucleosides separated on Aminex-A-6. Besides the physiological bases and 1,N6-ethenoadenosine, radioactivity was also incorporated into 3,N4-ethenocytidine. Radioactive 3,N4-ethenocytidine moieties were also formed on incubation of polycytidylic acid with rat liver microsomes, NADPH and [14C] vinyl chloride. These alkylation mechanisms are consistent with the mutagenic and cancerogenic properties of vinyl chloride.

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Year:  1978        PMID： 25061     DOI： 10.1007/BF00368232

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  20 in total

1.  Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation.

Authors:  H Greim; G Bonse; Z Radwan; D Reichert; D Henschler
Journal:  Biochem Pharmacol       Date:  1975-11-01       Impact factor: 5.858

2.  Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride.

Authors:  A Barbin; H Brésil; A Croisy; P Jacquignon; C Malaveille; R Montesano; H Bartsch
Journal:  Biochem Biophys Res Commun       Date:  1975-11-17       Impact factor: 3.575

3.  The biological fate in rats of vinyl chloride in relation to its oncogenicity.

Authors:  T Green; D E Hathway
Journal:  Chem Biol Interact       Date:  1975-12       Impact factor: 5.192

4.  Alkylation of DNA and proteins in mice exposed to vinyl chloride.

Authors:  S Osterman-Golkar; D Hultmark; D Segerbäck; C J Calleman; R Göthe; L Ehrenberg; C A Wachtmeister
Journal:  Biochem Biophys Res Commun       Date:  1976-05-23       Impact factor: 3.575

5.  Fate of (14C)vinyl chloride after single oral administration in rats.

Authors:  P G Watanabe; G R McGowan; P J Gehring
Journal:  Toxicol Appl Pharmacol       Date:  1976-05       Impact factor: 4.219

6.  Identification of two urine metabolites of vinyl chloride by GC-MS-investigations.

Authors:  G Müller; K Norpoth; R Eckard
Journal:  Int Arch Occup Environ Health       Date:  1976-10-21       Impact factor: 3.015

7.  Disposition of (1,2-14C) vinyl chloride in the rat.

Authors:  H M Bolt; H Kappus; A Buchter; W Bolt
Journal:  Arch Toxicol       Date:  1976-06-08       Impact factor: 5.153

8.  Vinyl chloride-induced depression of hepatic non-protein sulfhydryl content and effects on bromosulphalein (BSP) clearance in rats.

Authors:  P G Watanabe; R E Hefner; P J Gehring
Journal:  Toxicology       Date:  1976-06       Impact factor: 4.221

9.  The chemistry and biogenesis of the S-containing metabolites of vinyl chloride in rats.

Authors:  T Green; D E Hathway
Journal:  Chem Biol Interact       Date:  1977-05       Impact factor: 5.192

10.  Implication of rifampicin-quinone in the irreversible binding of rifampicin to macromolecules.

Authors:  H M Bolt; H Remmer
Journal:  Xenobiotica       Date:  1976-01       Impact factor: 1.908
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  12 in total

1.  A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-Oxoethyl)guanine in sprague-dawley rats.

Authors:  Esra Mutlu; Yo-Chan Jeong; Leonard B Collins; Amy-Joan L Ham; Patricia B Upton; Gary Hatch; Darrell Winsett; Paul Evansky; James A Swenberg
Journal:  Chem Res Toxicol       Date:  2012-01-24       Impact factor: 3.739

2.  Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.

Authors:  H Bartsch; C Malaveille; A Barbin; G Planche
Journal:  Arch Toxicol       Date:  1979-02-23       Impact factor: 5.153

3.  Reactions of vinyl chloride with RNA and DNA of various mouse tissues in vivo.

Authors:  K Bergman
Journal:  Arch Toxicol       Date:  1982-01       Impact factor: 5.153

Review 4.  Nucleic acid adducts of chemical carcinogens and mutagens.

Authors:  K Hemminki
Journal:  Arch Toxicol       Date:  1983-04       Impact factor: 5.153

5.  Covalent binding of drug metabolites to DNA--a tool of predictive value?

Authors:  H M Bolt; R J Laib
Journal:  Arch Toxicol       Date:  1980-11       Impact factor: 5.153

6.  Monooxygenase activity and ultrastructural changes of liver in the course of chronic exposure of rats to vinyl chloride.

Authors:  J M Wiśniewska-Knypl; J Klimczak; J Kołakowski
Journal:  Int Arch Occup Environ Health       Date:  1980       Impact factor: 3.015

7.  Vinyl chloride and trichloroethylene: comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver.

Authors:  R J Laib; G Stöckle; H M Bolt; W Kunz
Journal:  J Cancer Res Clin Oncol       Date:  1979-06-08       Impact factor: 4.553

8.  Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo.

Authors:  K Bergman
Journal:  Arch Toxicol       Date:  1983-11       Impact factor: 5.153

9.  Alkylation of RNA by vinyl bromide metabolites in vitro and in vivo.

Authors:  H Ottenwälder; R J Laib; H M Bolt
Journal:  Arch Toxicol       Date:  1979-02-23       Impact factor: 5.153

10.  Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis.

Authors:  A Barbin; H Bartsch; P Leconte; M Radman
Journal:  Nucleic Acids Res       Date:  1981-01-24       Impact factor: 16.971
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