BACKGROUND AND PURPOSE: The aim of this study is to explore the possible changed cerebral white matter regions in patients with temporal lobe epilepsy (TLE) using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). METHODS: Twenty TLE patients and 22 age- and gender-matched normal controls were included in this study. Voxel-wise analyses of multiple diffusion metrics, including fractional anisotropy (FA) and mean diffusivity (MD) were performed with TBSS. RESULTS: TLE patients exhibited significantly reduced FA in widespread white matter regions including bilateral limbic circuit, corpus callosum, thalamus, internal/external capsule, temporooccipital connections, frontotemporal connections; increase of MD was exhibited significantly almost in the left hemisphere. A significant decrease in global FA integrity was shown in epilepsy subjects compared to healthy controls. Furthermore, it exhibited a significant positive correlation between the disease duration and MD of whole brain. CONCLUSIONS: TLE is associated with widespread abnormalities in cerebral white matter tracts and these changes may have important clinical consequences.
BACKGROUND AND PURPOSE: The aim of this study is to explore the possible changed cerebral white matter regions in patients with temporal lobe epilepsy (TLE) using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). METHODS: Twenty TLEpatients and 22 age- and gender-matched normal controls were included in this study. Voxel-wise analyses of multiple diffusion metrics, including fractional anisotropy (FA) and mean diffusivity (MD) were performed with TBSS. RESULTS:TLEpatients exhibited significantly reduced FA in widespread white matter regions including bilateral limbic circuit, corpus callosum, thalamus, internal/external capsule, temporooccipital connections, frontotemporal connections; increase of MD was exhibited significantly almost in the left hemisphere. A significant decrease in global FA integrity was shown in epilepsy subjects compared to healthy controls. Furthermore, it exhibited a significant positive correlation between the disease duration and MD of whole brain. CONCLUSIONS:TLE is associated with widespread abnormalities in cerebral white matter tracts and these changes may have important clinical consequences.
Authors: Irena Buksakowska; Nikoletta Szabó; Lukáš Martinkovič; Péter Faragó; András Király; Jiří Vrána; Zsigmond Tamás Kincses; Jan Meluzín; Vlastimil Šulc; Martin Kynčl; Miloslav Roček; Michal Tichý; František Charvát; Daniel Hořínek; Petr Marusič Journal: Front Neurol Date: 2019-10-01 Impact factor: 4.003