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Literature DB >> 2506024

In vitro activity of cefoperazone-sulbactam combinations against cefoperazone-resistant clinical bacterial isolates.

G M Eliopoulos¹, K Klimm, M J Ferraro, R C Moellering.

Abstract

From July 1987 to January 1988, 452 cefoperazone-resistant bacterial isolates were identified among strains subjected to routine susceptibility testing in a clinical microbiology laboratory. The 452 isolates were tested for susceptibility to cefoperazone, sulbactam, and a 2:1 combination of these drugs by agar dilution techniques. The greatest benefit of the cefoperazone-sulbactam combination was noted against Bacteroides spp. and Acinetobacter spp. The combination demonstrated clinically significant synergism against approximately 20% of strains of Pseudomonas aeruginosa.

Entities: Chemical Species

Mesh：

Substances：
Cefoperazone
Sulbactam

Year: 1989 PMID： 2506024 DOI： 10.1007/bf01968142

Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN： 0934-9723 Impact factor: 3.267

4 in total

1. Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases.

Authors: L Gutmann; M D Kitzis; S Yamabe; J F Acar
Journal: Antimicrob Agents Chemother Date: 1986-05 Impact factor: 5.191

2. In vitro antimicrobial spectrum, occurrence of synergy, and recommendations for dilution susceptibility testing concentrations of the cefoperazone-sulbactam combination.

Authors: R N Jones; A L Barry; R R Packer; W W Gregory; C Thornsberry
Journal: J Clin Microbiol Date: 1987-09 Impact factor: 5.948

3. Comparative activity of beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with beta-lactams against beta-lactamase-producing anaerobes.

Authors: P C Appelbaum; M R Jacobs; S K Spangler; S Yamabe
Journal: Antimicrob Agents Chemother Date: 1986-11 Impact factor: 5.191

Review 4. Klebsiella pneumoniae and other Enterobacteriaceae producing novel plasmid-mediated beta-lactamases markedly active against third-generation cephalosporins: epidemiologic studies.

Authors: J Sirot; C Chanal; A Petit; D Sirot; R Labia; G Gerbaud
Journal: Rev Infect Dis Date: 1988 Jul-Aug

4 in total

3 in total

In vitro activity of cefoperazone-sulbactam combinations against cefoperazone-resistant clinical bacterial isolates.

1. Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases.

2. In vitro antimicrobial spectrum, occurrence of synergy, and recommendations for dilution susceptibility testing concentrations of the cefoperazone-sulbactam combination.

3. Comparative activity of beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with beta-lactams against beta-lactamase-producing anaerobes.

Review 4. Klebsiella pneumoniae and other Enterobacteriaceae producing novel plasmid-mediated beta-lactamases markedly active against third-generation cephalosporins: epidemiologic studies.

Review 1. β-Lactams and β-Lactamase Inhibitors: An Overview.

2. Comparison of efficacy of cefoperazone/sulbactam and imipenem/cilastatin for treatment of Acinetobacter bacteremia.

Review 3. Antibiotic resistance breakers: current approaches and future directions.