RATIONALE: Limited access nicotine self-administration decreases hippocampal neurogenesis, providing a mechanism for the deleterious effects of nicotine on hippocampal neuronal plasticity. However, recent studies have shown that limited access nicotine self-administration does not exhibit key features of nicotine dependence such as motivational withdrawal and increased motivation for nicotine after deprivation. OBJECTIVES: The present study used extended access nicotine self-administration (0.03 mg/kg/infusion, 21 h/day, 4 days) with intermittent periods of deprivation (3 days) for 14 weeks, to test the hypothesis that this model enhances nicotine seeking and produces distinct responses in hippocampal neurogenesis when compared with limited access (1 h/day, 4 days) intake. Animals in the extended access group were either perfused prior to or following their final deprivation period, whereas animals in the limited access group were perfused after their last session. RESULTS: Limited- and extended access nicotine self-administration with periodic deprivation did not affect proliferation and differentiation of oligodendrocyte progenitors in the medial prefrontal cortex (mPFC). Conversely, extended access nicotine self-administration with periodic deprivation enhanced proliferation and differentiation of hippocampal neural progenitors. Furthermore, in the hippocampus, the number of differentiating NeuroD-labeled cells strongly and positively correlated with enhanced nicotine seeking in rats that experienced extended access nicotine self-administration. CONCLUSIONS: These findings demonstrate that extended versus limited access to nicotine self-administration differentially affects the generation of new oligodendroglia and new neurons during adulthood. The increases in the number of differentiating cells in extended access nicotine self-administering rats may consequently contribute to aberrant hippocampal neurogenesis and may contribute to maladaptive addiction-like behaviors dependent on the hippocampus.
RATIONALE: Limited access nicotine self-administration decreases hippocampal neurogenesis, providing a mechanism for the deleterious effects of nicotine on hippocampal neuronal plasticity. However, recent studies have shown that limited access nicotine self-administration does not exhibit key features of nicotine dependence such as motivational withdrawal and increased motivation for nicotine after deprivation. OBJECTIVES: The present study used extended access nicotine self-administration (0.03 mg/kg/infusion, 21 h/day, 4 days) with intermittent periods of deprivation (3 days) for 14 weeks, to test the hypothesis that this model enhances nicotine seeking and produces distinct responses in hippocampal neurogenesis when compared with limited access (1 h/day, 4 days) intake. Animals in the extended access group were either perfused prior to or following their final deprivation period, whereas animals in the limited access group were perfused after their last session. RESULTS: Limited- and extended access nicotine self-administration with periodic deprivation did not affect proliferation and differentiation of oligodendrocyte progenitors in the medial prefrontal cortex (mPFC). Conversely, extended access nicotine self-administration with periodic deprivation enhanced proliferation and differentiation of hippocampal neural progenitors. Furthermore, in the hippocampus, the number of differentiating NeuroD-labeled cells strongly and positively correlated with enhanced nicotine seeking in rats that experienced extended access nicotine self-administration. CONCLUSIONS: These findings demonstrate that extended versus limited access to nicotine self-administration differentially affects the generation of new oligodendroglia and new neurons during adulthood. The increases in the number of differentiating cells in extended access nicotine self-administering rats may consequently contribute to aberrant hippocampal neurogenesis and may contribute to maladaptive addiction-like behaviors dependent on the hippocampus.
Authors: Adrianna Mendrek; John Monterosso; Sara L Simon; Murray Jarvik; Arthur Brody; Richard Olmstead; Catherine P Domier; Mark S Cohen; Monique Ernst; Edythe D London Journal: Addict Behav Date: 2005-07-11 Impact factor: 3.913
Authors: Laura E O'Dell; Scott A Chen; Ron T Smith; Sheila E Specio; Robert L Balster; Neil E Paterson; Athina Markou; Eric P Zorrilla; George F Koob Journal: J Pharmacol Exp Ther Date: 2006-10-18 Impact factor: 4.030
Authors: Alexander J Engelmann; Mark B Aparicio; Airee Kim; Jeffery C Sobieraj; Clara J Yuan; Yanabel Grant; Chitra D Mandyam Journal: Brain Struct Funct Date: 2013-02-27 Impact factor: 3.270
Authors: Leslie K Jacobsen; W Einar Mencl; R Todd Constable; Michael Westerveld; Kenneth R Pugh Journal: Psychopharmacology (Berl) Date: 2007-05-16 Impact factor: 4.415
Authors: Melissa H Galinato; Yoshio Takashima; McKenzie J Fannon; Leon W Quach; Roberto J Morales Silva; Karthik K Mysore; Michael J Terranova; Rahul R Dutta; Ryan W Ostrom; Sucharita S Somkuwar; Chitra D Mandyam Journal: J Neurosci Date: 2018-01-23 Impact factor: 6.167
Authors: McKenzie J Fannon; Karthik K Mysore; Jefferson Williams; Leon W Quach; Dvijen C Purohit; Britta D Sibley; Janna S Sage-Sepulveda; Khush M Kharidia; Roberto J Morales Silva; Michael J Terranova; Sucharita S Somkuwar; Miranda C Staples; Chitra D Mandyam Journal: Neuropharmacology Date: 2018-09-28 Impact factor: 5.250
Authors: Sucharita S Somkuwar; McKenzie J Fannon; Miranda C Staples; Eva R Zamora-Martinez; Alvaro I Navarro; Airee Kim; Jacqueline A Quigley; Scott Edwards; Chitra D Mandyam Journal: Brain Struct Funct Date: 2015-12-11 Impact factor: 3.270
Authors: Tracy T Smith; Matthew B Schaff; Laura E Rupprecht; Rachel L Schassburger; Deanne M Buffalari; Sharon E Murphy; Alan F Sved; Eric C Donny Journal: Drug Alcohol Depend Date: 2015-07-13 Impact factor: 4.492
Authors: Sucharita S Somkuwar; Miranda C Staples; Melissa H Galinato; McKenzie J Fannon; Chitra D Mandyam Journal: Front Pharmacol Date: 2014-12-19 Impact factor: 5.810