Literature DB >> 25057339

Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities.

Arshad H Rahmani1, Fahad M Al Shabrmi2, Salah M Aly3.   

Abstract

The current mode of treatment based on synthetic drugs is expensive and also causes genetic and metabolic alterations. However, safe and sound mode of treatment is needed to control the diseases development and progression. In this regards, medicinal plant and its constituents play an important role in diseases management via modulation of biological activities. Ginger, the rhizome of the Zingiber officinale, has shown therapeutic role in the health management since ancient time and considered as potential chemopreventive agent. Numerous studies based on clinical trials and animal model has shown that ginger and its constituents shows significant role in the prevention of diseases via modulation of genetic and metabolic activities. In this review, we focused on the therapeutics effects of ginger and its constituents in the diseases management, and its impact on genetic and metabolic activities.

Entities:  

Keywords:  Ginger; anti-microbial activity; anti-tumour activity; neuro-protector effect

Year:  2014        PMID: 25057339      PMCID: PMC4106649     

Source DB:  PubMed          Journal:  Int J Physiol Pathophysiol Pharmacol        ISSN: 1944-8171


  94 in total

1.  Effects of a ginger extract on knee pain in patients with osteoarthritis.

Authors:  R D Altman; K C Marcussen
Journal:  Arthritis Rheum       Date:  2001-11

2.  [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo.

Authors:  Eok-Cheon Kim; Jeong-Ki Min; Tae-Yoon Kim; Shin-Jeong Lee; Hyun-Ok Yang; Sanghwa Han; Young-Myeong Kim; Young-Guen Kwon
Journal:  Biochem Biophys Res Commun       Date:  2005-09-23       Impact factor: 3.575

3.  Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion.

Authors:  Yasunari Takada; Akira Murakami; Bharat B Aggarwal
Journal:  Oncogene       Date:  2005-10-20       Impact factor: 9.867

4.  6-gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice.

Authors:  Evan Prince Sabina; Samuel Joshua Pragasam; Suresh Kumar; Mahaboobkhan Rasool
Journal:  Zhong Xi Yi Jie He Xue Bao       Date:  2011-11

5.  Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin.

Authors:  Sue Ok Kim; Kyung-Soo Chun; Joydeb Kumar Kundu; Young-Joon Surh
Journal:  Biofactors       Date:  2004       Impact factor: 6.113

Review 6.  Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances.

Authors:  Y Surh
Journal:  Mutat Res       Date:  1999-07-16       Impact factor: 2.433

7.  Antioxidant and antimicrobial activity of Zingiberaceae plants in Taiwan.

Authors:  I-Nan Chen; Chen-Chin Chang; Chang-Chai Ng; Chung-Yi Wang; Yuan-Tay Shyu; Tsu-Liang Chang
Journal:  Plant Foods Hum Nutr       Date:  2007-12-20       Impact factor: 3.921

8.  Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol.

Authors:  R Aeschbach; J Löliger; B C Scott; A Murcia; J Butler; B Halliwell; O I Aruoma
Journal:  Food Chem Toxicol       Date:  1994-01       Impact factor: 6.023

9.  Suppressive effects of eugenol and ginger oil on arthritic rats.

Authors:  J N Sharma; K C Srivastava; E K Gan
Journal:  Pharmacology       Date:  1994-11       Impact factor: 2.547

10.  Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review.

Authors:  Yiming Li; Van H Tran; Colin C Duke; Basil D Roufogalis
Journal:  Evid Based Complement Alternat Med       Date:  2012-11-22       Impact factor: 2.629

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  34 in total

1.  6-Shogaol protects against ischemic acute kidney injury by modulating NF-κB and heme oxygenase-1 pathways.

Authors:  Sang Jun Han; Mihwa Kim; Vivette D D'Agati; H Thomas Lee
Journal:  Am J Physiol Renal Physiol       Date:  2019-07-17

2.  Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19.

Authors:  Elliot Nyagumbo; William Pote; Bridgett Shopo; Trust Nyirenda; Ignatius Chagonda; Ruvimbo J Mapaya; Fabian Maunganidze; William N Mavengere; Cephas Mawere; Ian Mutasa; Emmanuel Kademeteme; Alfred Maroyi; Tafadzwa Taderera; Michael Bhebhe
Journal:  Phys Chem Earth (2002)       Date:  2022-09-21       Impact factor: 3.311

3.  Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells.

Authors:  Nipin Sp; Dong Young Kang; Jin-Moo Lee; Se Won Bae; Kyoung-Jin Jang
Journal:  Int J Mol Sci       Date:  2021-04-28       Impact factor: 5.923

4.  Development of Coconut Milk-Based Spicy Ice Cream as a Nondairy Alternative with Desired Physicochemical and Sensory Attributes.

Authors:  K D S S Perera; O D A N Perera
Journal:  Int J Food Sci       Date:  2021-07-07

Review 5.  Elucidating the effect of anti-biofilm activity of bioactive compounds extracted from plants.

Authors:  Dibyajit Lahiri; Sudipta Dash; Rachayeeta Dutta; Moupriya Nag
Journal:  J Biosci       Date:  2019-06       Impact factor: 2.795

Review 6.  Aloe vera: Potential candidate in health management via modulation of biological activities.

Authors:  Arshad H Rahmani; Yousef H Aldebasi; Sauda Srikar; Amjad A Khan; Salah M Aly
Journal:  Pharmacogn Rev       Date:  2015 Jul-Dec

Review 7.  Cassia fistula Linn: Potential candidate in the health management.

Authors:  Arshad H Rahmani
Journal:  Pharmacognosy Res       Date:  2015 Jul-Sep

Review 8.  Implications of Green Tea and Its Constituents in the Prevention of Cancer via the Modulation of Cell Signalling Pathway.

Authors:  Arshad H Rahmani; Fahad M Al Shabrmi; Khaled S Allemailem; Salah M Aly; Masood A Khan
Journal:  Biomed Res Int       Date:  2015-04-21       Impact factor: 3.411

9.  The combined extract of purple waxy corn and ginger prevents cataractogenesis and retinopathy in streptozotocin-diabetic rats.

Authors:  Paphaphat Thiraphatthanavong; Jintanaporn Wattanathorn; Supaporn Muchimapura; Wipawee Thukham-mee; Kamol Lertrat; Bhalang Suriharn
Journal:  Oxid Med Cell Longev       Date:  2014-12-31       Impact factor: 6.543

10.  Identification of Novel Aldose Reductase Inhibitors from Spices: A Molecular Docking and Simulation Study.

Authors:  Priya Antony; Ranjit Vijayan
Journal:  PLoS One       Date:  2015-09-18       Impact factor: 3.240

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