Literature DB >> 25056864

Dual temperature multi-organ recovery from a Maastricht category III donor after circulatory death.

G C Oniscu1, A Siddique, J Dark.   

Abstract

Donation after circulatory death (DCD) makes a significant contribution to the transplant activity but is associated with significantly lower organ recovery rates and poorer function for the abdominal extra-renal organs compared with donation after brain death. Traditionally, DCD organ recovery involves cold thoracic and abdominal perfusion with a rapid removal of organs in order to minimize the ischemic damage. Novel approaches to organ recovery and preservation include the use of normothermic regional perfusion in the donor and ex vivo organ preservation. We report a new technique for multi-organ recovery from Maastricht category III donors with abdominal normothermic perfusion and concomitant cold lung flushing which allows a rapid removal of the lungs with preservation of the abdominal normothermic circulation throughout the thoracic procurement. This approach could lead to an increased organ recovery and better function for the abdominal organs. © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.

Entities:  

Keywords:  Clinical research; donation after circulatory death (DCD); donors and donation; extracorporeal membrane oxygenation (ECMO); organ perfusion and preservation; organ procurement and allocation; organ transplantation in general; practice; surgical technique

Mesh:

Year:  2014        PMID: 25056864     DOI: 10.1111/ajt.12808

Source DB:  PubMed          Journal:  Am J Transplant        ISSN: 1600-6135            Impact factor:   8.086


  2 in total

1.  Multiorgan retrieval and preservation of the thoracic and abdominal organs in Maastricht III donors.

Authors:  Daniel Casanova; Federico Castillo; Eduardo Miñambres
Journal:  World J Transplant       Date:  2022-05-18

Review 2.  Challenges and advances in optimizing liver allografts from donation after circulatory death donors.

Authors:  Andrew Ian Sutherland; Gabriel C Oniscu
Journal:  J Nat Sci Biol Med       Date:  2016 Jan-Jun
  2 in total

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