Literature DB >> 25056396

Prioritized current unmet needs for antibacterial therapies.

B Spellberg1, D Shlaes2.   

Abstract

As a result of declining new antibacterial approvals and rising antibiotic resistance, society clearly needs new treatments for bacterial infections. Specific areas of unmet need evolve over time owing to changes in resistance patterns and treatment strategies. Our goal here is to describe and prioritize the current areas of greatest unmet need for new antibacterial development based on an understanding of the most serious treatment challenges facing patients and their providers today.

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Year:  2014        PMID： 25056396     DOI： 10.1038/clpt.2014.106

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  16 in total

1.  Antibiotics: An irresistible newcomer.

Authors:  Gerard Wright
Journal:  Nature       Date:  2015-01-07       Impact factor: 49.962

2.  Reducing the Bottleneck in Discovery of Novel Antibiotics.

Authors:  Marcus B Jones; William C Nierman; Yue Shan; Bryan C Frank; Amy Spoering; Losee Ling; Aaron Peoples; Ashley Zullo; Kim Lewis; Karen E Nelson
Journal:  Microb Ecol       Date:  2016-11-28       Impact factor: 4.552

3.  A new antibiotic kills pathogens without detectable resistance.

Authors:  Losee L Ling; Tanja Schneider; Aaron J Peoples; Amy L Spoering; Ina Engels; Brian P Conlon; Anna Mueller; Till F Schäberle; Dallas E Hughes; Slava Epstein; Michael Jones; Linos Lazarides; Victoria A Steadman; Douglas R Cohen; Cintia R Felix; K Ashley Fetterman; William P Millett; Anthony G Nitti; Ashley M Zullo; Chao Chen; Kim Lewis
Journal:  Nature       Date:  2015-01-07       Impact factor: 49.962

4.  Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides.

Authors:  Wilmar Correa; Julius Brandenburg; Jochen Behrends; Lena Heinbockel; Norbert Reiling; Laura Paulowski; Dominik Schwudke; Kerstin Stephan; Guillermo Martinez-de-Tejada; Klaus Brandenburg; Thomas Gutsmann
Journal:  Biophys J       Date:  2019-10-18       Impact factor: 4.033

5.  Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.

Authors:  Gregory S Basarab; Gunther H Kern; John McNulty; John P Mueller; Kenneth Lawrence; Karthick Vishwanathan; Richard A Alm; Kevin Barvian; Peter Doig; Vincent Galullo; Humphrey Gardner; Madhusudhan Gowravaram; Michael Huband; Amy Kimzey; Marshall Morningstar; Amy Kutschke; Sushmita D Lahiri; Manos Perros; Renu Singh; Virna J A Schuck; Ruben Tommasi; Grant Walkup; Joseph V Newman
Journal:  Sci Rep       Date:  2015-07-14       Impact factor: 4.379

6.  Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens.

Authors:  David C McKinney; Gregory S Basarab; Alexis I Cocozaki; Melinda A Foulk; Matthew D Miller; Anatoly M Ruvinsky; Clay W Scott; Kumar Thakur; Liang Zhao; Ed T Buurman; Sridhar Narayan
Journal:  ACS Med Chem Lett       Date:  2015-07-12       Impact factor: 4.345

7.  Editorial Commentary: Ceftazidime-Avibactam and Carbapenem-Resistant Enterobacteriaceae: "We're Gonna Need a Bigger Boat".

Authors:  Brad Spellberg; Robert A Bonomo
Journal:  Clin Infect Dis       Date:  2016-09-13       Impact factor: 9.079

8.  Risks in Antibiotic Substitution Following Medicine Shortage: A Health-Care Failure Mode and Effect Analysis of Six European Hospitals.

Authors:  Nenad Miljković; Brian Godman; Eline van Overbeeke; Milena Kovačević; Karyofyllis Tsiakitzis; Athina Apatsidou; Anna Nikopoulou; Cristina Garcia Yubero; Laura Portillo Horcajada; Gunar Stemer; Darija Kuruc-Poje; Thomas De Rijdt; Tomasz Bochenek; Isabelle Huys; Branislava Miljković
Journal:  Front Med (Lausanne)       Date:  2020-05-12

9.  luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria.

Authors:  Carolyn A Brotherton; Marnix H Medema; E Peter Greenberg
Journal:  mSystems       Date:  2018-03-27       Impact factor: 6.496

10.  Multiparametric Profiling for Identification of Chemosensitizers against Gram-Negative Bacteria.

Authors:  Vincent Lôme; Jean-Michel Brunel; Jean-Marie Pagès; Jean-Michel Bolla
Journal:  Front Microbiol       Date:  2018-02-19       Impact factor: 5.640
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