B Ribba1, N Holford2, F Mentré3. 1. Inria, Project-Team NuMed, Ecole Normale Supérieure de Lyon, Lyon, France. 2. Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand. 3. IAME, UMR 1137, INSERM & Université Paris Diderot, Sorbonne Paris Cité, Paris, France.