BACKGROUND: Candida species represent the fourth leading cause of nosocomial bloodstream infections (BSI) worldwide. However, candidaemia rates and species involved vary geographically. OBJECTIVES: To evaluate the epidemiological pattern, risk factors for mortality and antifungal therapy of Candida BSI over a 5-year period (2008-2012) in a university hospital in northern Italy together with a review of the recent literature concerning candidaemia. METHODS: A retrospective cohort study cross-linked with microbiology database was performed. RESULTS: A total of 89 Candida BSI were identified in 42 males (47 %) and 47 females (52.8 %). The median age was 69 years (interquartile range 55-78) with 61.8 % of patients being older than 65 years. Considering all hospitalized patients, the overall incidence rate of candidaemia increased significantly from 2008 to 2012 (from 0.4 to 1.68 episodes per 10,000 patient/days) (p = 0.0001) with a mean linear increase in 5 new cases per year. Candida albicans was the predominant species isolated (64 %) followed by C. glabrata (19.1 %). The latter species was observed with significantly higher frequency in Internal Medicine and Intensive Care Units (ICU). In-hospital crude mortality was 41.6 %. CONCLUSIONS: Candidaemia is an increasing BSI in our university hospital, in accordance with that observed in northern Italy, and it is still associated with high in-hospital crude mortality.
BACKGROUND:Candida species represent the fourth leading cause of nosocomial bloodstream infections (BSI) worldwide. However, candidaemia rates and species involved vary geographically. OBJECTIVES: To evaluate the epidemiological pattern, risk factors for mortality and antifungal therapy of Candida BSI over a 5-year period (2008-2012) in a university hospital in northern Italy together with a review of the recent literature concerning candidaemia. METHODS: A retrospective cohort study cross-linked with microbiology database was performed. RESULTS: A total of 89 Candida BSI were identified in 42 males (47 %) and 47 females (52.8 %). The median age was 69 years (interquartile range 55-78) with 61.8 % of patients being older than 65 years. Considering all hospitalized patients, the overall incidence rate of candidaemia increased significantly from 2008 to 2012 (from 0.4 to 1.68 episodes per 10,000 patient/days) (p = 0.0001) with a mean linear increase in 5 new cases per year. Candida albicans was the predominant species isolated (64 %) followed by C. glabrata (19.1 %). The latter species was observed with significantly higher frequency in Internal Medicine and Intensive Care Units (ICU). In-hospital crude mortality was 41.6 %. CONCLUSIONS: Candidaemia is an increasing BSI in our university hospital, in accordance with that observed in northern Italy, and it is still associated with high in-hospital crude mortality.
Authors: O A Cornely; M Bassetti; T Calandra; J Garbino; B J Kullberg; O Lortholary; W Meersseman; M Akova; M C Arendrup; S Arikan-Akdagli; J Bille; E Castagnola; M Cuenca-Estrella; J P Donnelly; A H Groll; R Herbrecht; W W Hope; H E Jensen; C Lass-Flörl; G Petrikkos; M D Richardson; E Roilides; P E Verweij; C Viscoli; A J Ullmann Journal: Clin Microbiol Infect Date: 2012-12 Impact factor: 8.067
Authors: Mireia Puig-Asensio; Javier Pemán; Rafael Zaragoza; José Garnacho-Montero; Estrella Martín-Mazuelos; Manuel Cuenca-Estrella; Benito Almirante Journal: Crit Care Med Date: 2014-06 Impact factor: 7.598
Authors: Thomas A Clark; Sally A Slavinski; Juliette Morgan; Timothy Lott; Beth A Arthington-Skaggs; Mary E Brandt; Risa M Webb; Mary Currier; Richard H Flowers; Scott K Fridkin; Rana A Hajjeh Journal: J Clin Microbiol Date: 2004-10 Impact factor: 5.948
Authors: Peter G Pappas; John H Rex; Jeannette Lee; Richard J Hamill; Robert A Larsen; William Powderly; Carol A Kauffman; Newton Hyslop; Julie E Mangino; Stanley Chapman; Harold W Horowitz; John E Edwards; William E Dismukes Journal: Clin Infect Dis Date: 2003-08-14 Impact factor: 9.079
Authors: M T Montagna; G Lovero; E Borghi; G Amato; S Andreoni; L Campion; G Lo Cascio; G Lombardi; F Luzzaro; E Manso; M Mussap; P Pecile; S Perin; E Tangorra; M Tronci; R Iatta; G Morace Journal: Eur Rev Med Pharmacol Sci Date: 2014 Impact factor: 3.507
Authors: Hee Kyoung Choi; Su Jin Jeong; Han Sung Lee; Bum Sik Chin; Suk Hoon Choi; Sang Hoon Han; Myung Soo Kim; Chang Oh Kim; Jun Yong Choi; Young Goo Song; June Myung Kim Journal: Korean J Intern Med Date: 2009-08-26 Impact factor: 2.884
Authors: Andrea Ripoli; Emanuela Sozio; Francesco Sbrana; Giacomo Bertolino; Carlo Pallotto; Gianluigi Cardinali; Simone Meini; Filippo Pieralli; Anna Maria Azzini; Ercole Concia; Bruno Viaggi; Carlo Tascini Journal: Infection Date: 2020-08-01 Impact factor: 3.553
Authors: Sarah G Whaley; Elizabeth L Berkow; Jeffrey M Rybak; Andrew T Nishimoto; Katherine S Barker; P David Rogers Journal: Front Microbiol Date: 2017-01-12 Impact factor: 5.640
Authors: Maria Helena Galdino Figueiredo-Carvalho; Livia de Souza Ramos; Leonardo Silva Barbedo; Alessandra Leal da Silva Chaves; Ilda Akemi Muramoto; André Luis Souza dos Santos; Rodrigo Almeida-Paes; Rosely Maria Zancopé-Oliveira Journal: Mem Inst Oswaldo Cruz Date: 2016-01 Impact factor: 2.743