PURPOSE OF THE STUDY: To assess the role of migraine history in the development of postoperative nausea and vomiting (PONV) in patients undergoing general and combined general-epidural anaesthesia. MATERIALS AND METHODS: 127 women with oncogynecological pathology were randomized into 3 groups according to anaesthesia method. Patients of the group C (comparative group; n = 43; 18 with migraine) received general anaesthesia. Patients of the Group CA (n = 40; 19 with migraine) received combined general-epidural anaesthesia. Patients of the group D (n = 44; 19 with migraine) received general anaesthesia with adding of Droperidolum. All patients received standard prophylactics of PONV- Ondansetronum 8 mg and dexamethasone 8 mg intravenous. RESULTS: In the group C a PONV occurred in 15 of 43 women (34.9%). PONV occurred in 6 of 18 women with migraine (33.3%) and in 9 of 25 women without migraine (36%). In the group CA a PONV occurred in 10 of 40 women (25%). PONV occurred in 8 of 19 women with migraine (42.1%) and in 2 of 21 women without migraine (9.5%; p = 0.036 in comparison with group C). In the group D a PONV occurred in 8 of 44 women (18.2%). PONV occurred in 1 of 19 women with migraine (5.3% p = 0.03 in comparison with group C and p = 0.008 with group CA) and in 7 of 25 women without migraine (28%; there was no significant difference with groups C and CA). CONCLUSIONS: Migraine history is a significant risk factor of PONV. Epidural component of anaesthesia does not effect on frequency of PONV in women with migraine, but Droperidolum use allows increasing the frequency of PONV.
RCT Entities:
PURPOSE OF THE STUDY: To assess the role of migraine history in the development of postoperative nausea and vomiting (PONV) in patients undergoing general and combined general-epidural anaesthesia. MATERIALS AND METHODS: 127 women with oncogynecological pathology were randomized into 3 groups according to anaesthesia method. Patients of the group C (comparative group; n = 43; 18 with migraine) received general anaesthesia. Patients of the Group CA (n = 40; 19 with migraine) received combined general-epidural anaesthesia. Patients of the group D (n = 44; 19 with migraine) received general anaesthesia with adding of Droperidolum. All patients received standard prophylactics of PONV- Ondansetronum 8 mg and dexamethasone 8 mg intravenous. RESULTS: In the group C a PONV occurred in 15 of 43 women (34.9%). PONV occurred in 6 of 18 women with migraine (33.3%) and in 9 of 25 women without migraine (36%). In the group CA a PONV occurred in 10 of 40 women (25%). PONV occurred in 8 of 19 women with migraine (42.1%) and in 2 of 21 women without migraine (9.5%; p = 0.036 in comparison with group C). In the group D a PONV occurred in 8 of 44 women (18.2%). PONV occurred in 1 of 19 women with migraine (5.3% p = 0.03 in comparison with group C and p = 0.008 with group CA) and in 7 of 25 women without migraine (28%; there was no significant difference with groups C and CA). CONCLUSIONS:Migraine history is a significant risk factor of PONV. Epidural component of anaesthesia does not effect on frequency of PONV in women with migraine, but Droperidolum use allows increasing the frequency of PONV.