Literature DB >> 25055011

mTOR: a new therapeutic target for pediatric low-grade glioma?

Fausto J Rodriguez1, Eric H Raabe.   

Abstract

Entities:  

Keywords:  mTOR; neurofibromatosis; optic nerve; pediatric glioma; pilocytic astrocytoma

Mesh：

Substances：

Year:  2014        PMID： 25055011      PMCID： PMC4322914          DOI： 10.2217/cns.14.4

Source DB:  PubMed          Journal:  CNS Oncol        ISSN： 2045-0907


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  18 in total

1.  Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group.

Authors:  Joann L Ater; Tianni Zhou; Emiko Holmes; Claire M Mazewski; Timothy N Booth; David R Freyer; Ken H Lazarus; Roger J Packer; Michael Prados; Richard Sposto; Gilbert Vezina; Jeffrey H Wisoff; Ian F Pollack
Journal:  J Clin Oncol       Date:  2012-06-04       Impact factor: 44.544

2.  BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.

Authors:  Eric H Raabe; Kah Suan Lim; Julia M Kim; Alan Meeker; Xing-Gang Mao; Guido Nikkhah; Jarek Maciaczyk; Ulf Kahlert; Deepali Jain; Eli Bar; Kenneth J Cohen; Charles G Eberhart
Journal:  Clin Cancer Res       Date:  2011-06-01       Impact factor: 12.531

3.  Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas.

Authors:  Karine Jacob; Dongh-Anh Quang-Khuong; David T W Jones; Hendrik Witt; Sally Lambert; Steffen Albrecht; Olaf Witt; Catherine Vezina; Margret Shirinian; Damien Faury; Miklos Garami; Peter Hauser; Almos Klekner; Laszlo Bognar; Jean-Pierre Farmer; Jose-Luis Montes; Jeffrey Atkinson; Cynthia Hawkins; Andrey Korshunov; V Peter Collins; Stefan M Pfister; Uri Tabori; Nada Jabado
Journal:  Clin Cancer Res       Date:  2011-05-24       Impact factor: 12.531

4.  PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma.

Authors:  Erika F Rodriguez; Bernd W Scheithauer; Caterina Giannini; Amanda Rynearson; Ling Cen; Bridget Hoesley; Heather Gilmer-Flynn; Jann N Sarkaria; Sarah Jenkins; Jin Long; Fausto J Rodriguez
Journal:  Acta Neuropathol       Date:  2010-11-28       Impact factor: 17.088

5.  Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

Authors:  Sutapa Banerjee; Nikkilina R Crouse; Ryan J Emnett; Scott M Gianino; David H Gutmann
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-06       Impact factor: 11.205

6.  The pharmacology of mTOR inhibition.

Authors:  David A Guertin; David M Sabatini
Journal:  Sci Signal       Date:  2009-04-21       Impact factor: 8.192

7.  Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: prospective evaluation of cognitive, endocrine, and hearing deficits.

Authors:  Thomas E Merchant; Heather M Conklin; Shengjie Wu; Robert H Lustig; Xiaoping Xiong
Journal:  J Clin Oncol       Date:  2009-07-06       Impact factor: 44.544

8.  Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma.

Authors:  Eli E Bar; Alex Lin; Tarik Tihan; Peter C Burger; Charles G Eberhart
Journal:  J Neuropathol Exp Neurol       Date:  2008-09       Impact factor: 3.685

9.  BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas.

Authors:  Stefan Pfister; Wibke G Janzarik; Marc Remke; Aurélie Ernst; Wiebke Werft; Natalia Becker; Grischa Toedt; Andrea Wittmann; Christian Kratz; Heike Olbrich; Rezvan Ahmadi; Barbara Thieme; Stefan Joos; Bernhard Radlwimmer; Andreas Kulozik; Torsten Pietsch; Christel Herold-Mende; Astrid Gnekow; Guido Reifenberger; Andrey Korshunov; Wolfram Scheurlen; Heymut Omran; Peter Lichter
Journal:  J Clin Invest       Date:  2008-05       Impact factor: 14.808

10.  Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas.

Authors:  David T W Jones; Sylvia Kocialkowski; Lu Liu; Danita M Pearson; L Magnus Bäcklund; Koichi Ichimura; V Peter Collins
Journal:  Cancer Res       Date:  2008-11-01       Impact factor: 12.701
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  4 in total

1.  Inhibition of mTORC1 in pediatric low-grade glioma depletes glutathione and therapeutically synergizes with carboplatin.

Authors:  Brad Poore; Ming Yuan; Antje Arnold; Antoinette Price; Jesse Alt; Jeffrey A Rubens; Barbara S Slusher; Charles G Eberhart; Eric H Raabe
Journal:  Neuro Oncol       Date:  2019-02-14       Impact factor: 12.300

2.  High LC3/Beclin Expression Correlates with Poor Survival in Glioma: a Definitive Role for Autophagy as Evidenced by In Vitro Autophagic Flux.

Authors:  Padmakrishnan Cj; Easwer Hv; Vinod Vijayakurup; Girish R Menon; Suresh Nair; Srinivas Gopala
Journal:  Pathol Oncol Res       Date:  2017-10-11       Impact factor: 3.201

3.  mTOR activation is increased in pilocytic astrocytomas from older adults compared with children.

Authors:  Mahlon D Johnson; Mary O'Connell; Kevin Walter; Howard Silberstein
Journal:  Surg Neurol Int       Date:  2017-05-26

4.  A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma.

Authors:  Karen D Wright; Xiaopan Yao; Wendy B London; Pei-Chi Kao; Lia Gore; Stephen Hunger; Russ Geyer; Kenneth J Cohen; Jeffrey C Allen; Howard M Katzenstein; Amy Smith; Jessica Boklan; Kellie Nazemi; Tanya Trippett; Matthias Karajannis; Cynthia Herzog; Joseph Destefano; Jennifer Direnzo; Jay Pietrantonio; Lianne Greenspan; Danielle Cassidy; Debra Schissel; John Perentesis; Mitali Basu; Tomoyuki Mizuno; Alexander A Vinks; Sanjay P Prabhu; Susan N Chi; Mark W Kieran
Journal:  Pediatr Blood Cancer       Date:  2020-11-02       Impact factor: 3.838
  4 in total

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