Ronaldo Lessa1, Maurício Castillo2, Renata Azevedo3, Fernanda Azevedo4, Hildo Azevedo5. 1. Setor de Radiologia, Universidade de Pernambuco, Recife, PE, Brazil. 2. University of North Carolina, Chapel Hill, North Carolina, United States. 3. Setor de Neurologia, Hospital Santa Joana, Recife, PE, Brazil. 4. Setor de Neurologia, Hospital Correia Picanço, Recife, PE, Brazil. 5. Universidade de Pernambuco, Recife, PE, Brazil.
Abstract
OBJECTIVE: To report 4 different neurological complications of H1N1 virus vaccination. METHOD: Four patients (9, 16, 37 and 69 years of age) had neurological symptoms (intracranial hypertension, ataxia, left peripheral facial palsy of abrupt onset, altered mental status, myelitis) starting 4-15 days after H1N1 vaccination. MRI was obtained during the acute period. RESULTS: One patient with high T2 signal in the cerebellum interpreted as acute cerebellitis; another, with left facial palsy, showed contrast enhancement within both internal auditory canals was present, however it was more important in the right side; one patient showed gyriform hyperintensities on FLAIR with sulcal effacement in the right fronto-parietal region; and the last one showed findings compatible with thoracic myelitis. CONCLUSION: H1N1 vaccination can result in important neurological complications probably secondary to post-vaccination inflammation. MRI detected abnormalities in all patients.
OBJECTIVE: To report 4 different neurological complications of H1N1 virus vaccination. METHOD: Four patients (9, 16, 37 and 69 years of age) had neurological symptoms (intracranial hypertension, ataxia, left peripheral facial palsy of abrupt onset, altered mental status, myelitis) starting 4-15 days after H1N1 vaccination. MRI was obtained during the acute period. RESULTS: One patient with high T2 signal in the cerebellum interpreted as acute cerebellitis; another, with left facial palsy, showed contrast enhancement within both internal auditory canals was present, however it was more important in the right side; one patient showed gyriform hyperintensities on FLAIR with sulcal effacement in the right fronto-parietal region; and the last one showed findings compatible with thoracic myelitis. CONCLUSION:H1N1 vaccination can result in important neurological complications probably secondary to post-vaccination inflammation. MRI detected abnormalities in all patients.
Authors: Yair Zlotnik; Avi Gadoth; Ibrahim Abu-Salameh; Anat Horev; Rosa Novoa; Gal Ifergane Journal: Front Immunol Date: 2022-01-05 Impact factor: 7.561