Literature DB >> 25054871

Experimental model of Achilles tendon injury in rats.

Flavia Emi Akamatsu1, Samir Omar Saleh2, Walcy Rosolia Teodoro3, Alexandre Queiroz da Silva2, Carlos Augusto Real Martinez4, Ricardo Jordão Duarte5, Mauro Figueiredo Carvalho de Andrade6, Alfredo Luiz Jacomo6.   

Abstract

PURPOSE: To describe an effective experimental model to study the Achilles tendon healing.
METHODS: Forty male Rattus norvegicus albinus, Wistar lineage adult male weighing 250 to 300g were used for this experiment and thirty were surgically submitted to bilateral partial transverse section of the Achilles tendon. The right tendon was treated with radio waves (RF) whereas the left tendon served as control. On the third postoperative day, the rats were divided into four experimental groups consisting of ten rats each which were treated with monopolar RF adjusted to 650 kHz and 2w, for two minutes twice a week and a group of normal animals without any intervention, until they were sacrificed on the 7th, 14th and 28th days, respectively. Tendons were weighed and collagen quantification was evaluated by hydroxyprolin content.
RESULTS: Significant reduction in collagen content on day 7, 14 and 28 was related to control experiment to normal tendon (7 days, p<0.01; 14 e 28 days, p<0.05).
CONCLUSION: The experimental model has been effective and available to be used to study Achilles tendon healing.

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Year:  2014        PMID: 25054871     DOI: 10.1590/s0102-86502014000700002

Source DB:  PubMed          Journal:  Acta Cir Bras        ISSN: 0102-8650            Impact factor:   1.388


  2 in total

1.  Photobiomodulation therapy increases collagen II after tendon experimental injury.

Authors:  Flávia Emi Akamatsu; Walcy Rosolia Teodoro; Ana Maria Itezerote; Lizandre Keren Ramos da Silveira; Samir Saleh; Carlos Augusto Real Martinez; Marcelo Lima Ribeiro; José Aires Pereira; Flávio Hojaij; Mauro Andrade; Alfredo Luiz Jacomo
Journal:  Histol Histopathol       Date:  2021-03-23       Impact factor: 2.303

2.  Effects of Apixaban, Rivaroxaban, Dabigatran and Enoxaparin on Histopathology and Laboratory Parameters in Achilles Tendon Injury: An in vivo Study.

Authors:  Sema Avci; Huseyin Gungor; Alper Serhat Kumru; Mahmut Sahin; Arzu Gezer; Uzeyir Gok; Haki Kara; Mucahit Avcil
Journal:  Saudi J Med Med Sci       Date:  2021-06-23
  2 in total

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