Literature DB >> 25054605

When anti-TNF fails, anti-IL12-23 is an alternate option in psoriasis and psoriatic arthritis.

Ricardo Prado Golmia, Ayk Helena Barbosa Martins, Morton Scheinberg.   

Abstract

Patients with psoriasis and psoriatic arthritis respond to anti-TNF therapy, but not all patients maintain effective response, and some do not respond. In this article, we demonstrate the role of a new pathogenetic pathway to some extent TNF-independent in these patients. Anti-IL12-23 is a new and alternate mode of therapy for patients with recalcitrant response to anti-TNF.

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Year:  2014        PMID: 25054605

Source DB:  PubMed          Journal:  Rev Bras Reumatol        ISSN: 0482-5004


  2 in total

1.  Secukinumab sustains improvement in signs and symptoms of psoriatic arthritis: 2 year results from the phase 3 FUTURE 2 study.

Authors:  Iain B McInnes; Philip J Mease; Christopher T Ritchlin; Proton Rahman; Alice B Gottlieb; Bruce Kirkham; Radhika Kajekar; Eumorphia-Maria Delicha; Luminita Pricop; Shephard Mpofu
Journal:  Rheumatology (Oxford)       Date:  2017-11-01       Impact factor: 7.580

2.  Efficacy and safety of secukinumab administration by autoinjector in patients with psoriatic arthritis: results from a randomized, placebo-controlled trial (FUTURE 3).

Authors:  Peter Nash; Philip J Mease; Iain B McInnes; Proton Rahman; Christopher T Ritchlin; Ricardo Blanco; Eva Dokoupilova; Mats Andersson; Radhika Kajekar; Shephard Mpofu; Luminita Pricop
Journal:  Arthritis Res Ther       Date:  2018-03-15       Impact factor: 5.156

  2 in total

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