| Literature DB >> 25054213 |
Kai-Bo Wang1, Ying-Tong Di, Yu Bao, Chun-Mao Yuan, Gang Chen, Da-Hong Li, Jiao Bai, Hong-Ping He, Xiao-Jiang Hao, Yue-Hu Pei, Yong-Kui Jing, Zhan-Lin Li, Hui-Ming Hua.
Abstract
Peganumine A (1), a new dimeric β-carboline alkaloid characterized by a unique 3,9-diazatetracyclo[6.5.2.0(1,9).0(3,8)]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 μM.Entities:
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Year: 2014 PMID： 25054213 DOI： 10.1021/ol501856v
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005