| Literature DB >> 2505415 |
Abstract
Jun is a transcription factor that can also induce oncogenic transformation. Its DNA-binding domain is conserved from yeast to man and shows homology to several other transcriptional regulators. Jun dimerizes with the fos protein through an alpha-helical domain termed the leucine zipper, and the jun-fos heterodimers bind to DNA and regulate transcription of numerous specific unlinked genes.Entities:
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Year: 1989 PMID: 2505415 DOI: 10.1016/0968-0004(89)90268-5
Source DB: PubMed Journal: Trends Biochem Sci ISSN: 0968-0004 Impact factor: 13.807