Romulus Timar1, Bogdan Timar2, Diana Degeratu3, Cristian Serafinceanu4, Cristian Oancea5. 1. Department of Internal Medicine II, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania. 2. Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania timar.bogdan@umft.ro. 3. City Hospital, Timisoara, Romania. 4. Department of Diabetes Nutrition and Metabolic Diseases, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. 5. Department of Infectious Diseases, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Abstract
OBJECTIVES: To assess the prevalence of metabolic syndrome and evaluate proinflammatory status in patients with type 1 diabetes, and to analyse the relationship between inflammation, metabolic control and insulin resistance in these patients. METHODS: Patients with type 1 diabetes were stratified according to the presence or absence of metabolic syndrome. Serum adiponectin, leptin, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and high-sensitivity C-reactive protein (hsCRP) were quantified. RESULTS: The prevalence of metabolic syndrome was 28.6% (22/77). Patients with metabolic syndrome had lower adiponectin concentrations and higher leptin, TNF-α, IL-6 and hsCRP concentrations compared with patients without metabolic syndrome. In addition, metabolic syndrome was associated with higher glycosylated haemoglobin and insulin dose, and increased insulin resistance. CONCLUSIONS: The proinflammatory state associated with metabolic syndrome in patients with type 1 diabetes leads to deterioration of glycaemic control and an increase in the required daily dose of insulin. Early and proactive diagnosis of metabolic syndrome in these patients will allow medication and lifestyle optimization, in order to prevent the occurrence of diabetes complications and improve health-related quality-of-life.
OBJECTIVES: To assess the prevalence of metabolic syndrome and evaluate proinflammatory status in patients with type 1 diabetes, and to analyse the relationship between inflammation, metabolic control and insulin resistance in these patients. METHODS:Patients with type 1 diabetes were stratified according to the presence or absence of metabolic syndrome. Serum adiponectin, leptin, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and high-sensitivity C-reactive protein (hsCRP) were quantified. RESULTS: The prevalence of metabolic syndrome was 28.6% (22/77). Patients with metabolic syndrome had lower adiponectin concentrations and higher leptin, TNF-α, IL-6 and hsCRP concentrations compared with patients without metabolic syndrome. In addition, metabolic syndrome was associated with higher glycosylated haemoglobin and insulin dose, and increased insulin resistance. CONCLUSIONS: The proinflammatory state associated with metabolic syndrome in patients with type 1 diabetes leads to deterioration of glycaemic control and an increase in the required daily dose of insulin. Early and proactive diagnosis of metabolic syndrome in these patients will allow medication and lifestyle optimization, in order to prevent the occurrence of diabetes complications and improve health-related quality-of-life.
Authors: Katarzyna Siewko; Rafal Maciulewski; Anna Zielinska-Maciulewska; Anna Poplawska-Kita; Piotr Szumowski; Natalia Wawrusiewicz-Kurylonek; Danuta Lipinska; Robert Milewski; Maria Gorska; Adam Kretowski; Malgorzata Szelachowska Journal: Biomed Res Int Date: 2019-10-20 Impact factor: 3.411
Authors: Leandro C Freitas Lima; Valdir de Andrade Braga; Maria do Socorro de França Silva; Josiane de Campos Cruz; Sérgio H Sousa Santos; Matheus M de Oliveira Monteiro; Camille de Moura Balarini Journal: Front Physiol Date: 2015-11-03 Impact factor: 4.566