Joel Nuotio1, Mervi Oikonen2, Costan G Magnussen3, Eero Jokinen4, Tomi Laitinen5, Nina Hutri-Kähönen6, Mika Kähönen7, Terho Lehtimäki8, Leena Taittonen9, Päivi Tossavainen10, Antti Jula11, Britt-Marie Loo11, Jorma Sa Viikari12, Olli T Raitakari13, Markus Juonala12. 1. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland jovanu@utu.fi. 2. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. 3. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. 4. Department of Paediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. 5. Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. 6. Department of Pediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland. 7. Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Tampere, Finland. 8. Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland. 9. Vaasa Central Hospital, Vaasa, Finland Department of Pediatrics, University of Oulu, Oulu, Finland. 10. Department of Pediatrics, University of Oulu, Oulu, Finland. 11. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland. 12. Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland. 13. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland The Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Abstract
AIMS: Cardiovascular risk factor levels in 2011 and 4-year changes between 2007 and 2011 were examined using data collected in follow-ups of the Cardiovascular Risk in Young Finns Study. METHODS: The study population comprised 2063 Finnish adults aged 34-49 years (45% male). Lipid and blood pressure levels, glucose and anthropometry were measured and life style risk factors examined with questionnaires. RESULTS: Mean total cholesterol level in 2011 was 5.19 mmol/l, low density lipoprotein (LDL)-cholesterol 3.27 mmol/l, high density lipoprotein (HDL)-cholesterol 1.33 mmol/l, and triglycerides 1.34 mmol/l. Using American Diabetes Association criteria, Type 2 diabetes (T2D) was observed in 4.1% and prediabetes (fasting glucose 5.6-6.9 mmol/l or glycated hemoglobin 5.7-6.4%) diagnosed for 33.8% of the participants. Significant changes (P < 0.05) between 2007 and 2011 included an increase in waist circumference (3.3%) in women. In both sexes, systolic (-3.0% in women, -4.0% in men) and diastolic (-3.0% in women, -3.3% in men) blood pressure and triglycerides (-3.4% in women, -6.5% in men) decreased during follow-up. CONCLUSIONS: Previously observed favorable trends in ldl-cholesterol levels have leveled off among a sample of young and middle-aged adults in finland triglyceride and blood pressure levels have decreased over one-third of the study population had prediabetes and may be at increased risk for T2D:
AIMS: Cardiovascular risk factor levels in 2011 and 4-year changes between 2007 and 2011 were examined using data collected in follow-ups of the Cardiovascular Risk in Young Finns Study. METHODS: The study population comprised 2063 Finnish adults aged 34-49 years (45% male). Lipid and blood pressure levels, glucose and anthropometry were measured and life style risk factors examined with questionnaires. RESULTS: Mean total cholesterol level in 2011 was 5.19 mmol/l, low density lipoprotein (LDL)-cholesterol 3.27 mmol/l, high density lipoprotein (HDL)-cholesterol 1.33 mmol/l, and triglycerides 1.34 mmol/l. Using American Diabetes Association criteria, Type 2 diabetes (T2D) was observed in 4.1% and prediabetes (fasting glucose 5.6-6.9 mmol/l or glycated hemoglobin 5.7-6.4%) diagnosed for 33.8% of the participants. Significant changes (P < 0.05) between 2007 and 2011 included an increase in waist circumference (3.3%) in women. In both sexes, systolic (-3.0% in women, -4.0% in men) and diastolic (-3.0% in women, -3.3% in men) blood pressure and triglycerides (-3.4% in women, -6.5% in men) decreased during follow-up. CONCLUSIONS: Previously observed favorable trends in ldl-cholesterol levels have leveled off among a sample of young and middle-aged adults in finland triglyceride and blood pressure levels have decreased over one-third of the study population had prediabetes and may be at increased risk for T2D:
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