Literature DB >> 2505331

Hepatic protection by 16, 16-dimethyl prostaglandin E2 (DMPG) against acute aflatoxin B1-induced injury in the rat.

B D Rush1, K F Wilkinson, N M Nichols, R Ochoa, M N Brunden, M J Ruwart.   

Abstract

Studies were conducted to assess the possible protective action of 16,16-dimethyl prostaglandin E2 (DMPG) against acute aflatoxin B1 (AFB1) induced hepatic injury in the rat. Evaluation of liver damage by histopathologic techniques and clinical chemistry indicated that hepatic necrosis was ameliorated by treatment with DMPG even though binding of radiolabeled (3H)-AFB1 to hepatic DNA was unaffected by this prostaglandin. However, DMPG did not protect rats against AFB1-induced mortality. These data suggest that hepatic protection by DMPG was due to mechanisms other than an interference with the activation or hepatic binding of AFB1.

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Year:  1989        PMID： 2505331     DOI： 10.1016/0090-6980(89)90105-6

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  10 in total

Review 1.  Cell biology of liver endothelial and Kupffer cells.

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2.  TNF-alpha dependent production of inducible nitric oxide is involved in PGE(1) protection against acute liver injury.

Authors:  J Muntané; F J Rodríguez; O Segado; A Quintero; J M Lozano; E Siendones; C A Pedraza; M Delgado; F O'Valle; R García; J L Montero; M De La Mata; G Miño
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3.  Preventive effect of FK 506 (tacrolimus hydrate) on experimentally induced acute liver injury in rats.

Authors:  K Uchida; I Sakaida; K Hironaka; K Kayano; K Okita
Journal:  Dig Dis Sci       Date:  2000-10       Impact factor: 3.199

4.  Liver cirrhosis induces renal and liver phospholipase A2 activity in rats.

Authors:  B S Vishwanath; F J Frey; G Escher; J Reichen; B M Frey
Journal:  J Clin Invest       Date:  1996-07-15       Impact factor: 14.808

5.  Misoprostol protection against acetaminophen-induced hepatotoxicity in the rat.

Authors:  S P Lim; F J Andrews; P E O'Brien
Journal:  Dig Dis Sci       Date:  1994-06       Impact factor: 3.199

6.  Attenuation of acetaminophen hepatitis by prostaglandin E2. A histopathological study.

Authors:  G L Monto; P J Scheuer; R L Hansing; A K Burroughs
Journal:  Dig Dis Sci       Date:  1994-05       Impact factor: 3.199

7.  Arachidonate metabolism in D-galactosamine or carbon tetrachloride-induced acute and chronic liver injuries in rats.

Authors:  P Liu; N Kawada; Y Mizoguchi; S Morisawa
Journal:  Gastroenterol Jpn       Date:  1992-10

8.  Preventative effect of PGE1 for postoperative liver damage.

Authors:  N Iwatsuki; A Yasuda; S Tokutomi; T Saishu; Y Koga; Y Hashimoto
Journal:  J Anesth       Date:  1992-04       Impact factor: 2.078

9.  Cytoprotection by iloprost against paracetamol-induced toxicity in hamster isolated hepatocytes.

Authors:  P Nasseri-Sina; D J Fawthrop; J Wilson; A R Boobis; D S Davies
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

Review 10.  Liver cytoprotection by prostaglandins.

Authors:  J Quiroga; J Prieto
Journal:  Pharmacol Ther       Date:  1993       Impact factor: 12.310
  10 in total

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