Literature DB >> 2504990

Interleukin-6 and its receptor during homeostasis, inflammation, and tumor growth.

J Bauer1.   

Abstract

This review focuses on describing the specific role of interleukin-6 within the network of inflammatory mediators in man. Sites of interleukin-6 synthesis, regulation of its expression, and the biological functions of this molecule are here outlined. The potential role of interleukin-6 as a diagnostic monitor is discussed. Particular attention is paid to experimental evidence that interleukin-6 and its receptor may be involved in the pathogenesis of autocrine tumor growth. A recently proposed therapeutical use of cytotoxic interleukin-6 fusion proteins in order to selectively, destroy certain interleukin-6 receptor bearing tumor cells is discussed in the light of the finding, that not only hepatocytes, but also normal peripheral blood monocytes express the interleukin-6 receptor.

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Year:  1989        PMID： 2504990     DOI： 10.1007/bf01721287

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  121 in total

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Journal:  Annu Rev Immunol       Date:  1988       Impact factor: 28.527

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Journal:  Biochem Biophys Res Commun       Date:  1988-06-30       Impact factor: 3.575

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Journal:  Blood       Date:  1988-06       Impact factor: 22.113

9.  Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells.

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Journal:  J Exp Med       Date:  1987-03-01       Impact factor: 14.307
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  12 in total

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Journal:  Rheumatol Int       Date:  1996       Impact factor: 2.631

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Journal:  Inflammation       Date:  1995-02       Impact factor: 4.092

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Authors:  U Sack; R W Kinne; T Marx; P Heppt; S Bender; F Emmrich
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Review 7.  Interleukin-6 in clinical medicine.

Authors:  J Bauer; F Herrmann
Journal:  Ann Hematol       Date:  1991-06       Impact factor: 3.673

8.  Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients.

Authors:  M Huell; S Strauss; B Volk; M Berger; J Bauer
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

9.  Functional heterogeneity and pathogenic significance of interleukin-6 in B-cell lymphomas.

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Review 10.  Inflammatory mechanisms in Alzheimer's disease.

Authors:  M Hüll; S Strauss; M Berger; B Volk; J Bauer
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1996       Impact factor: 5.270
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