| Literature DB >> 2504888 |
P Gallo1, M G Piccinno, S Pagni, V Argentiero, B Giometto, F Bozza, B Tavolato.
Abstract
Serum and cerebrospinal fluid (CSF) levels of interleukin-2 (IL-2), soluble IL-2 receptor (sIL-2R), and gamma-interferon (gamma-IFN) were measured in multiple sclerosis (MS) patients, human immunodeficiency virus type 1 (HIV-1)-infected patients and normal controls (NC). Increased levels of both IL-2 and sIL-2R were found in MS serum. Moreover, 11 of 50 MS patients showed detectable levels of IL-2 in the CSF. HIV-1-infected patients had increased levels of sIL-2R in serum and, less frequently, in the CSF. gamma-IFN was never detected in serum and CSF of all the patients studied. These findings confirm preliminary reports, further stress a systemic T-cell activation in MS, and support the hypothesis that an immunologic disorder exists in such patients.Entities:
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Year: 1989 PMID： 2504888 DOI： 10.1016/0022-510x(89)90171-8
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181