| Literature DB >> 25048781 |
Michele Dal Bo1, Erika Tissino1, Dania Benedetti1, Chiara Caldana1, Riccardo Bomben1, Giovanni Del Poeta2, Gianluca Gaidano3, Francesca Maria Rossi1, Antonella Zucchetto1, Valter Gattei4.
Abstract
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation/expansion of a clonal population of neoplastic cells with the morphologic appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. A combination of genetic lesions is primarily responsible for the first step(s) of neoplastic transformation, along with microenvironmental signals, which concurrently operate by enhancing proliferation and/or inhibiting apoptosis. In this context, CD49d is known to play a pivotal role in mediating both cell-cell and cell-matrix interactions in CLL-involved tissues, eventually delivering pro-survival signals and protecting CLL cells from drug-induced damages. In the present review, we address, in detail, CD49d activities in the CLL microenvironment, CD49d functional and physical interactions with other microenvironmental receptors (including CD38 and B-cell receptor), and the relationship of CD49d expression with specific cytogenetic features in CLL.Entities:
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Year: 2014 PMID： 25048781 DOI： 10.1053/j.seminhematol.2014.05.002
Source DB: PubMed Journal: Semin Hematol ISSN： 0037-1963 Impact factor: 3.851