BACKGROUND: Patients with urothelial carcinoma (UC) often develop multifocal metachronous tumors throughout the genitourinary tract. In the present study, we evaluated the prognostic value of prior history of UC of the bladder (UCB) in patients with upper tract urothelial carcinoma (UTUC) in an international multi-institutional cohort. PATIENTS AND METHODS: Data from 785 patients who underwent radical nephroureterectomy (RNU) with ipsilateral bladder cuff resection at nine academic institutions in Europe and the USA between 1987 and 2008 were reviewed. Log-rank tests and Cox proportional hazards regression models were used for univariable and multivariable analyses. RESULTS: The median follow-up of the whole cohort was 34 months (interquartile range 15-66 months). Five hundred and fifty-eight (72 %) patients had no UCB before the diagnosis of UTUC; a prior history of non-muscle-invasive and muscle-invasive UCB before the UTUC was found in 179 (23 %) and 36 (5 %), respectively. History of UCB before RNU was an independent predictor of both recurrence-free survival (p = 0.012; no UCB vs. non-muscle-invasive UCB: hazard ratio (HR) 1.4, p = 0.082; no UCB vs. muscle-invasive UCB: HR 2.1, p = 0.007) and cancer-specific survival (p = 0.008; no UCB vs. non-muscle-invasive UCB: HR 1.2, p = 0.279; no UCB vs. muscle-invasive UCB: HR 2.3, p = 0.008) on multivariable Cox regression analyses that included age, gender, surgical type, stage, grade, presence of concomitant carcinoma in situ, presence of lymphovascular invasion, and lymph node status. CONCLUSIONS: Prior history of muscle-invasive UCB was significantly associated with an increased risk of disease recurrence and cancer-specific death in patients with UTUC.
BACKGROUND:Patients with urothelial carcinoma (UC) often develop multifocal metachronous tumors throughout the genitourinary tract. In the present study, we evaluated the prognostic value of prior history of UC of the bladder (UCB) in patients with upper tract urothelial carcinoma (UTUC) in an international multi-institutional cohort. PATIENTS AND METHODS: Data from 785 patients who underwent radical nephroureterectomy (RNU) with ipsilateral bladder cuff resection at nine academic institutions in Europe and the USA between 1987 and 2008 were reviewed. Log-rank tests and Cox proportional hazards regression models were used for univariable and multivariable analyses. RESULTS: The median follow-up of the whole cohort was 34 months (interquartile range 15-66 months). Five hundred and fifty-eight (72 %) patients had no UCB before the diagnosis of UTUC; a prior history of non-muscle-invasive and muscle-invasive UCB before the UTUC was found in 179 (23 %) and 36 (5 %), respectively. History of UCB before RNU was an independent predictor of both recurrence-free survival (p = 0.012; no UCB vs. non-muscle-invasive UCB: hazard ratio (HR) 1.4, p = 0.082; no UCB vs. muscle-invasive UCB: HR 2.1, p = 0.007) and cancer-specific survival (p = 0.008; no UCB vs. non-muscle-invasive UCB: HR 1.2, p = 0.279; no UCB vs. muscle-invasive UCB: HR 2.3, p = 0.008) on multivariable Cox regression analyses that included age, gender, surgical type, stage, grade, presence of concomitant carcinoma in situ, presence of lymphovascular invasion, and lymph node status. CONCLUSIONS: Prior history of muscle-invasive UCB was significantly associated with an increased risk of disease recurrence and cancer-specific death in patients with UTUC.
Authors: Giacomo Novara; Vincenzo De Marco; Fedra Gottardo; Orietta Dalpiaz; Vianney Bouygues; Antonio Galfano; Guido Martignoni; Jean Jacques Patard; Walter Artibani; Vincenzo Ficarra Journal: Cancer Date: 2007-10-15 Impact factor: 6.860
Authors: Evanguelos Xylinas; Luis Kluth; Niccolo Passoni; Quoc-Dien Trinh; Malte Rieken; Richard K Lee; Harun Fajkovic; Giacomo Novara; Vitaly Margulis; Jay D Raman; Yair Lotan; Morgan Rouprêt; Atiqullah Aziz; Hans-Martin Fritsche; Alon Weizer; Juan I Martinez-Salamanca; Kazumasa Matsumoto; Christian Seitz; Mesut Remzi; Thomas Walton; Pierre I Karakiewicz; Francesco Montorsi; Marc Zerbib; Douglas S Scherr; Shahrokh F Shariat Journal: Eur Urol Date: 2013-09-19 Impact factor: 20.096
Authors: Feng Jin; Jose Thaiparambil; Sri Ramya Donepudi; Venkatrao Vantaku; Danthasinghe Waduge Badrajee Piyarathna; Suman Maity; Rashmi Krishnapuram; Vasanta Putluri; Franklin Gu; Preeti Purwaha; Salil Kumar Bhowmik; Chandrashekar R Ambati; Friedrich-Carl von Rundstedt; Florian Roghmann; Sebastian Berg; Joachim Noldus; Kimal Rajapakshe; Daniel Gödde; Stephan Roth; Stephan Störkel; Stephan Degener; George Michailidis; Benny Abraham Kaipparettu; Balasubramanyam Karanam; Martha K Terris; Shyam M Kavuri; Seth P Lerner; Farrah Kheradmand; Cristian Coarfa; Arun Sreekumar; Yair Lotan; Randa El-Zein; Nagireddy Putluri Journal: Cancer Prev Res (Phila) Date: 2017-08-29