OBJECTIVE: To investigate the different patterns of bone spur formation in psoriatic arthritis (PsA) and hand osteoarthritis (OA), using high-resolution peripheral quantitative computed tomography (QCT). METHODS: The study group comprised 70 subjects (25 patients with PsA, 25 patients with hand OA, and 20 healthy controls). The 2 patient groups were similar with regard to age and sex distribution and clinical involvement of the metacarpophalangeal (MCP) joints. All patients underwent high-resolution peripheral QCT scanning of the second, third, and fourth MCP joints of the dominantly affected hand. Demographic and disease-specific data were recorded, and the number, size, and distribution of bone spurs were assessed and compared between patients with PsA and patients with hand OA. RESULTS: The overall number and size of bone spurs were similar in patients with PsA and patients with hand OA. However, localization of lesions within individual joints was substantially different between patients with PsA and those with hand OA. In PsA, bone spurs dominated the radial sides of the joints (for the metacarpal head of the second joint, P < 0.001 versus hand OA; for the base of the second phalangeal joint, P < 0.001 versus hand OA), whereas the palmar and dorsal quadrants were the predilection sites in hand OA. Detailed anatomic analysis showed that bone spurs in the entheseal regions were prominent in patients with PsA but rare in patients with hand OA, and that bone spurs in patients with hand OA typically emerged at the cartilage-bone interphase and the joint margins. CONCLUSION: Our findings show that the overall number and size of bone spurs are similar in patients with PsA and patients with hand OA. Nonetheless, the anatomic sites of bone proliferation are different between these 2 groups of patients.
OBJECTIVE: To investigate the different patterns of bone spur formation in psoriatic arthritis (PsA) and hand osteoarthritis (OA), using high-resolution peripheral quantitative computed tomography (QCT). METHODS: The study group comprised 70 subjects (25 patients with PsA, 25 patients with hand OA, and 20 healthy controls). The 2 patient groups were similar with regard to age and sex distribution and clinical involvement of the metacarpophalangeal (MCP) joints. All patients underwent high-resolution peripheral QCT scanning of the second, third, and fourth MCP joints of the dominantly affected hand. Demographic and disease-specific data were recorded, and the number, size, and distribution of bone spurs were assessed and compared between patients with PsA and patients with hand OA. RESULTS: The overall number and size of bone spurs were similar in patients with PsA and patients with hand OA. However, localization of lesions within individual joints was substantially different between patients with PsA and those with hand OA. In PsA, bone spurs dominated the radial sides of the joints (for the metacarpal head of the second joint, P < 0.001 versus hand OA; for the base of the second phalangeal joint, P < 0.001 versus hand OA), whereas the palmar and dorsal quadrants were the predilection sites in hand OA. Detailed anatomic analysis showed that bone spurs in the entheseal regions were prominent in patients with PsA but rare in patients with hand OA, and that bone spurs in patients with hand OA typically emerged at the cartilage-bone interphase and the joint margins. CONCLUSION: Our findings show that the overall number and size of bone spurs are similar in patients with PsA and patients with hand OA. Nonetheless, the anatomic sites of bone proliferation are different between these 2 groups of patients.
Authors: D Wu; J F Griffith; S H M Lam; P Wong; J Yue; L Shi; E K Li; I T Cheng; T K Li; V W Hung; L Qin; L-S Tam Journal: Osteoporos Int Date: 2020-01-14 Impact factor: 4.507
Authors: Georg Schett; Proton Rahman; Christopher Ritchlin; Iain B McInnes; Dirk Elewaut; Jose U Scher Journal: Nat Rev Rheumatol Date: 2022-05-05 Impact factor: 20.543
Authors: Arnd Kleyer; Laura Beyer; Christoph Simon; Fabian Stemmler; Matthias Englbrecht; Christian Beyer; Jürgen Rech; Bernhard Manger; Gerhard Krönke; Georg Schett; Axel J Hueber Journal: Arthritis Res Ther Date: 2017-02-10 Impact factor: 5.156
Authors: Eleni Kampylafka; Isabelle d'Oliveira; Christina Linz; Veronika Lerchen; Fabian Stemmler; David Simon; Matthias Englbrecht; Michael Sticherling; Jürgen Rech; Arnd Kleyer; Georg Schett; Axel J Hueber Journal: Arthritis Res Ther Date: 2018-07-27 Impact factor: 5.156
Authors: Tomohiro Shimizu; Hyo Jin Choi; Ursula Heilmeier; Matthew Tanaka; Andrew J Burghardt; Jingshan Gong; Nattagan Chanchek; Thomas M Link; Jonathan Graf; John B Imboden; Xiaojuan Li Journal: Arthritis Res Ther Date: 2017-10-04 Impact factor: 5.156