Sevtap Hekimoglu Sahin1, Dilek Memiş2, Erkan Celik3, Necdet Sut4. 1. Department of Anesthesiology and Reanimation, Trakya University Medical Faculty, Edirne, 22030, Turkey. sevtaphekimoglu@mynet.com. 2. Department of Anesthesiology and Reanimation, Trakya University Medical Faculty, Edirne, 22030, Turkey. dilmemis@mynet.com. 3. Department of Anesthesiology and Reanimation, Trakya University Medical Faculty, Edirne, 22030, Turkey. erkanc@mynet.com. 4. Department of Biostatistics, Trakya University Medical Faculty, Edirne, Turkey. necdetsut@yahoo.com.
Abstract
PURPOSE: The aim of this prospective study was to determine the efficacy of intraarticular levobupivacaine with and without intravenous dexketoprofen trometamol for postarthroscopy analgesia. METHODS:Sixty patients who underwent arthroscopic knee surgery were randomly assigned to three treatment groups. When the surgical procedure was completed, patients received the following treatments: group I (n = 20) patients received 20 mLintraarticular normal saline and 2 mL intravenous dexketoprofen trometamol (50 mg); group II (n = 20) patients received 20 mLintraarticular 0.5 % levobupivacaine (100 mg) and 2 mL intravenous normal saline; and group III (n = 20) patients received 20 mLintraarticular 0.5 % levobupivacaine (100 mg) and 2 mL intravenous dexketoprofen trometamol (50 mg). The visual analogue scale (VAS) was used, and the total analgesic consumption was assessed at 1, 2, 4, 6, 12, and 24 h post-operatively. RESULTS: The VAS scores at 1, 2, 4, 6, 12, and 24 h post-operatively were significantly increased in group I and group II compared with group III (p < 0.05). The average VAS score during the first 24 h post-operatively was significantly lower in group III than in group I and group II (p < 0.001). Total meperidine consumption was significantly lower in group III than in groups I and II (p < 0.001). CONCLUSION:Intraarticular levobupivacaine with adjuvant intravenous dexketoprofen trometamol administration provided better pain relief and less analgesic requirement after arthroscopic knee surgery during the first 24 h than that induced by dexketoprofen alone or levobupivacaine intraarticular alone. LEVEL OF EVIDENCE: II.
RCT Entities:
PURPOSE: The aim of this prospective study was to determine the efficacy of intraarticular levobupivacaine with and without intravenous dexketoprofen trometamol for postarthroscopy analgesia. METHODS: Sixty patients who underwent arthroscopic knee surgery were randomly assigned to three treatment groups. When the surgical procedure was completed, patients received the following treatments: group I (n = 20) patients received 20 mL intraarticular normal saline and 2 mL intravenous dexketoprofen trometamol (50 mg); group II (n = 20) patients received 20 mL intraarticular 0.5 % levobupivacaine (100 mg) and 2 mL intravenous normal saline; and group III (n = 20) patients received 20 mL intraarticular 0.5 % levobupivacaine (100 mg) and 2 mL intravenous dexketoprofen trometamol (50 mg). The visual analogue scale (VAS) was used, and the total analgesic consumption was assessed at 1, 2, 4, 6, 12, and 24 h post-operatively. RESULTS: The VAS scores at 1, 2, 4, 6, 12, and 24 h post-operatively were significantly increased in group I and group II compared with group III (p < 0.05). The average VAS score during the first 24 h post-operatively was significantly lower in group III than in group I and group II (p < 0.001). Total meperidine consumption was significantly lower in group III than in groups I and II (p < 0.001). CONCLUSION: Intraarticular levobupivacaine with adjuvant intravenous dexketoprofen trometamol administration provided better pain relief and less analgesic requirement after arthroscopic knee surgery during the first 24 h than that induced by dexketoprofen alone or levobupivacaine intraarticular alone. LEVEL OF EVIDENCE: II.
Authors: Eva Jacobson; Hamid Assareh; Ronnie Cannerfelt; Russell E Anderson; Jan G Jakobsson Journal: Knee Surg Sports Traumatol Arthrosc Date: 2005-06-10 Impact factor: 4.342
Authors: J Beltrán; E Martín-Mola; M Figueroa; J Granados; R Sanmartí; R Artigas; F Torres; M Forns; D Mauleón Journal: J Clin Pharmacol Date: 1998-12 Impact factor: 3.126
Authors: M R Panara; A Greco; G Santini; M G Sciulli; M T Rotondo; R Padovano; M di Giamberardino; F Cipollone; F Cuccurullo; C Patrono Journal: Br J Pharmacol Date: 1995-11 Impact factor: 8.739