Literature DB >> 25046583

Palladium-catalyzed direct C7-arylation of substituted indazoles.

Mohammed Naas1, Saïd El Kazzouli, El Mokhtar Essassi, Mosto Bousmina, Gérald Guillaumet.   

Abstract

A novel direct C7-arylation of indazoles with iodoaryls is described using Pd(OAc)2 as catalyst, 1,10-phenanthroline as ligand, and K2CO3 as base in refluxing DMA. Direct C7-arylation of 3-substituted 1H-indazole containing an EWG on the arene ring gave the expected products in good isolated yields. In addition, a one-pot Suzuki-Miyaura/arylation procedure leading to C3,C7-diarylated indazoles has been developed.

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Year:  2014        PMID： 25046583     DOI： 10.1021/jo500876q

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  "On Water" Palladium Catalyzed Direct Arylation of 1H-Indazole and 1H-7-Azaindazole.

Authors:  Khadija Gambouz; Abdelmoula El Abbouchi; Sarah Nassiri; Franck Suzenet; Mostapha Bousmina; Mohamed Akssira; Gérald Guillaumet; Saïd El Kazzouli
Journal:  Molecules       Date:  2020-06-18       Impact factor: 4.411

2.  A regioselective C7 bromination and C7 palladium-catalyzed Suzuki-Miyaura cross-coupling arylation of 4-substituted NH-free indazoles.

Authors:  Khalid Boujdi; Nabil El Brahmi; Jérôme Graton; Didier Dubreuil; Sylvain Collet; Monique Mathé-Allainmat; Mohamed Akssira; Jacques Lebreton; Saïd El Kazzouli
Journal:  RSC Adv       Date:  2021-02-10       Impact factor: 3.361
  2 in total

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