Literature DB >> 25046229

Value of GATA3 immunostaining in the diagnosis of parathyroid tumors.

Nelson G Ordóñez1.   

Abstract

GATA3 is a transcription factor that is involved in the embryonic development of the parathyroid glands and in adult parathyroid cell proliferation. The aim of this study is to investigate the expression of GATA3 in parathyroid tumors and to determine whether it could be used as an immunohistochemical marker for parathyroid differentiation in tumors. Immunoreactivity for GATA3 was nuclear and was demonstrated in all 10 hyperplastic parathyroid glands, 22 parathyroid adenomas, and 6 parathyroid carcinomas; whereas, all thyroid tumors, renal cell carcinomas, thymic epithelial tumors, and carcinoid tumors investigated for comparison purposes were negative for this marker. It is concluded that GATA3 is a very sensitive and relatively specific immunohistochemical marker for parathyroid differentiation that can assist in the differential diagnosis of parathyroid tumors.

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Year:  2014        PMID： 25046229     DOI： 10.1097/PAI.0000000000000007

Source DB:  PubMed          Journal:  Appl Immunohistochem Mol Morphol        ISSN： 1533-4058


  9 in total

1.  Expression, function, and regulation of the embryonic transcription factor TBX1 in parathyroid tumors.

Authors:  Chiara Verdelli; Laura Avagliano; Vito Guarnieri; Filomena Cetani; Stefano Ferrero; Leonardo Vicentini; Edoardo Beretta; Alfredo Scillitani; Pasquale Creo; Gaetano Pietro Bulfamante; Valentina Vaira; Sabrina Corbetta
Journal:  Lab Invest       Date:  2017-09-18       Impact factor: 5.662

Review 2.  GATA factors in endocrine neoplasia.

Authors:  Marjut Pihlajoki; Anniina Färkkilä; Tea Soini; Markku Heikinheimo; David B Wilson
Journal:  Mol Cell Endocrinol       Date:  2015-05-28       Impact factor: 4.102

3.  In Vitro Control of Genes Critical for Parathyroid Embryogenesis by Extracellular Calcium.

Authors:  Sergio Fabbri; Roberto Zonefrati; Gianna Galli; Giorgio Gronchi; Giuliano Perigli; Andrea Borrelli; Maria Luisa Brandi
Journal:  J Endocr Soc       Date:  2020-05-25

Review 4.  Immunohistochemical Biomarkers in Thyroid Pathology.

Authors:  Zubair Baloch; Ozgur Mete; Sylvia L Asa
Journal:  Endocr Pathol       Date:  2018-06       Impact factor: 3.943

5.  Immunohistochemical distinction of paragangliomas from epithelial neuroendocrine tumors-gangliocytic duodenal and cauda equina paragangliomas align with epithelial neuroendocrine tumors.

Authors:  Divya Mamilla; Irena Manukyan; Patricia A Fetsch; Karel Pacak; Markku Miettinen
Journal:  Hum Pathol       Date:  2020-07-12       Impact factor: 3.466

6.  GATA3-Positive Adnexal Adenocarcinoma: Report of a Confusing Case with a Potential Pitfall of Leading to a Misdiagnosis of Urothelial Carcinoma and a Review of Published Work.

Authors:  Takahiro Kiyohara; Hirotsugu Tanimura
Journal:  Ann Dermatol       Date:  2020-09-29       Impact factor: 1.444

7.  GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15.

Authors:  Ming Zhao; Lixin Zhou; Li Sun; Yan Song; Yunquan Guo; Xun Zhang; Feng Zhao; Peng Wang; Junqiu Yue; Dongfeng Niu; Zhongwu Li; Xiaozheng Huang; Qiang Kang; Lin Jia; Jinping Lai; Dengfeng Cao
Journal:  Diagn Pathol       Date:  2017-07-10       Impact factor: 2.644

8.  Mammaglobin, GATA-binding protein 3 (GATA3), and epithelial growth factor receptor (EGFR) expression in different breast cancer subtypes and their clinical significance.

Authors:  Xin Kong; Qi Wang; Jie Li; Ming Li; Fusheng Deng; Chuanying Li
Journal:  Eur J Histochem       Date:  2022-04-07       Impact factor: 1.966

9.  The input of GATA-3 in the identification of parathyroid carcinoma diagnosis: Case report with review of literature.

Authors:  Zainab Lajmi; Ahlem Bdioui; Ahlem Bchir; Emene Ben Ammou; Nabiha Missaoui; Sihem Hmissa
Journal:  Ann Med Surg (Lond)       Date:  2021-07-14
  9 in total

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