| Literature DB >> 25044500 |
Sylvia T Gunawan1, Kang Liang, Georgina K Such, Angus P R Johnston, Melissa K M Leung, Jiwei Cui, Frank Caruso.
Abstract
The engineering of layer-by-layer (LbL) hybrid click capsules that are responsive to biological stimuli is reported. The capsules comprise a pH-sheddable, non cross-linked outer coating that protects enzyme-cleavable inner layers. Upon cellular uptake, the outer coating is released and the capsules are enzymatically degraded. In vitro cell degradation results in rapid capsule degradation (10 min) upon cellular internalization.Keywords: click chemistry; enzyme-responsive; layer-by-layer (LbL); nanotechnology; polymer capsules
Mesh：
Substances：
Year: 2014 PMID： 25044500 DOI： 10.1002/smll.201400450
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281