Literature DB >> 2504447

Effect of nalidixic acid on DNA repair in rat hepatocytes.

C A McQueen1, R R Rosado, G M Williams.   

Abstract

Nalidixic acid, a DNA topoisomerase inhibitor, has been reported to inhibit DNA repair in some mammalian systems. To investigate the effect of nalidixic acid on DNA repair in cultured rat hepatocytes, DNA damage was induced by ultraviolet light or N-methyl-N-nitro-N'-nitrosoguanidine. The presence of aphidicolin, a DNA polymerase alpha inhibitor resulted in a decrease in DNA repair. Nalidixic acid had no inhibitory effect. Neither aphidicolin nor nalidixic acid induced DNA repair. These results indicate that nalidixic acid does not damage DNA or inhibit DNA repair processes in hepatocytes.

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Year:  1989        PMID： 2504447     DOI： 10.1007/bf00122653

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  12 in total

1.  Eukaryotic DNA repair is blocked at different steps by inhibitors of DNA topoisomerases and of DNA polymerases alpha and beta.

Authors:  M R Mattern; R F Paone; R S Day
Journal:  Biochim Biophys Acta       Date:  1982-04-26

2.  The effect of various inhibitors of DNA synthesis on the repair of DNA photoproducts.

Authors:  J M Clarkson; D L Mitchell
Journal:  Biochim Biophys Acta       Date:  1983-09-09

3.  The inhibition of DNA repair in primary rat hepatocyte cultures by aphidicolin: evidence for the involvement of alpha polymerase in the repair process.

Authors:  E Bermúdez
Journal:  Biochem Biophys Res Commun       Date:  1982-11-16       Impact factor: 3.575

Review 4.  DNA gyrase and the supercoiling of DNA.

Authors:  N R Cozzarelli
Journal:  Science       Date:  1980-02-29       Impact factor: 47.728

5.  Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts.

Authors:  P Hussy; G Maass; B Tümmler; F Grosse; U Schomburg
Journal:  Antimicrob Agents Chemother       Date:  1986-06       Impact factor: 5.191

6.  Stimulation of DNA repair synthesis of rat thymocytes by novobiocin and nalidixic acid in vitro without detectable DNA damage.

Authors:  K Tempel; A Spath
Journal:  Arch Toxicol       Date:  1987-06       Impact factor: 5.153

7.  Quinolone antibiotics inhibit eucaryotic DNA polymerase alpha and beta, terminal deoxynucleotidyl transferase but not DNA ligase.

Authors:  R Rusquet; M Bonhommet; J C David
Journal:  Biochem Biophys Res Commun       Date:  1984-06-29       Impact factor: 3.575

8.  Direct inhibition of u.v.-induced DNA excision repair in human cells by novobiocin, coumermycin and nalidixic acid.

Authors:  S L Dresler; R M Robinson-Hill
Journal:  Carcinogenesis       Date:  1987-06       Impact factor: 4.944

9.  Dependence of mammalian DNA synthesis on DNA supercoiling. III. Characterization of the inhibition of replicative and repair-type DNA synthesis by novobiocin and nalidixic acid.

Authors:  M R Mattern; D A Scudiero
Journal:  Biochim Biophys Acta       Date:  1981-04-27

10.  Evidence that novobiocin and nalidixic acid do not inhibit excision repair in u.v.-irradiated human skin fibroblasts at a pre-incision step.

Authors:  S M Keyse; R M Tyrrell
Journal:  Carcinogenesis       Date:  1985-08       Impact factor: 4.944
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  2 in total

1.  DNA single stranded gaps formed during DNA repair synthesis induced by methyl methanesulfonate are filled by sequential action of aphidicolin- and dideoxythymidine sensitive DNA polymerases in HeLa cells.

Authors:  I S Park; J K Park; H Y Koh; S D Park
Journal:  Cell Biol Toxicol       Date:  1991-01       Impact factor: 6.691

2.  The effects of inhibitors of topoisomerase II and quinacrine on ultraviolet-light-induced DNA incision in normal and xeroderma pigmentosum fibroblasts.

Authors:  H W Thielmann; O Popanda; L Edler
Journal:  J Cancer Res Clin Oncol       Date:  1991       Impact factor: 4.553
  2 in total

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