| Literature DB >> 25044435 |
Katja Benner1, Anna Bergen, Heiko Ihmels, Phil Marvin Pithan.
Abstract
Biaryl derivatives that consist of one DNA-intercalating unit and a sterically demanding component exhibit a specific behavior towards abasic site-containing DNA (AP-DNA) as determined by thermal DNA denaturation experiments, spectrometric titrations and CD spectroscopic analysis. Specifically, these ligands strongly stabilize AP-DNA towards dissociation, whereas they do not or only marginally affect the melting temperature of regular duplex DNA.Keywords: DNA damage; DNA ligands; DNA recognition; abasic DNA; nitrogen heterocycles
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Year: 2014 PMID： 25044435 DOI： 10.1002/chem.201403622
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236