| Literature DB >> 2504440 |
Y Ishizaki1, I Morita, S Murota.
Abstract
Arachidonic acid metabolism in primary cultures of astroglial cells prepared from cerebra of rat embryos was examined. Arachidonic acid was mainly metabolized through the lipoxygenase pathway and the major metabolites formed were 12-hydroxyeicosatetraenoic acid (12-HETE), 11-HETE and 15-HETE. By contrast, in C6 cells, which are considered to be of astroglial origin, arachidonic acid was mainly metabolized through the cyclooxygenase pathway and the major metabolites formed were prostaglandin (PG)E2, PGF2 alpha and thromboxane B2.Entities:
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Year: 1989 PMID： 2504440 DOI： 10.1016/0006-8993(89)90152-2
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252