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Literature DB >> 25044298

Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets.

Peng Zhao¹, Zitian Chen, Yizhou Li, Dawei Sun, Yuan Gao, Yanyi Huang, Xiaoyu Li.

Abstract

The selection of DNA-encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement of modified and immobilized targets remains a significant disadvantage. With a terminal protection strategy and ligand-induced photo-crosslinking, we show that iterated selections of DNA-encoded libraries can be realized with unmodified and non-immobilized protein targets.

Keywords: DNA; DNA-encoded library; DNA-templated chemistry; drug discovery; selection

Mesh：

Substances：

Year: 2014 PMID： 25044298 DOI： 10.1002/anie.201404830

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

19 in total

1. Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells.

Authors: Bo Cai; Dongwook Kim; Saeed Akhand; Yixing Sun; Robert J Cassell; Aktan Alpsoy; Emily C Dykhuizen; Richard M Van Rijn; Michael K Wendt; Casey J Krusemark
Journal: J Am Chem Soc Date: 2019-10-22 Impact factor: 15.419

Review 2. DNA-encoded chemistry: enabling the deeper sampling of chemical space.

Authors: Robert A Goodnow; Christoph E Dumelin; Anthony D Keefe
Journal: Nat Rev Drug Discov Date: 2016-12-09 Impact factor: 84.694

3. Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries.

Authors: Kyle E Denton; Casey J Krusemark
Journal: Medchemcomm Date: 2016-08-02 Impact factor: 3.597

4. Comparative evaluation of DNA-encoded chemical selections performed using DNA in single-stranded or double-stranded format.

Authors: Gabriele Bassi; Nicholas Favalli; Sebastian Oehler; Adriano Martinelli; Marco Catalano; Jörg Scheuermann; Dario Neri
Journal: Biochem Biophys Res Commun Date: 2020-05-05 Impact factor: 3.575

Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets.

1. Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells.

Review 2. DNA-encoded chemistry: enabling the deeper sampling of chemical space.

3. Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries.

4. Comparative evaluation of DNA-encoded chemical selections performed using DNA in single-stranded or double-stranded format.

Review 5. DNA-encoded chemical libraries - achievements and remaining challenges.

6. Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries.

7. Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection.

Review 8. DNA-encoded chemical libraries: foundations and applications in lead discovery.

9. Automated screening for small organic ligands using DNA-encoded chemical libraries.

Review 10. Novel selection methods for DNA-encoded chemical libraries.