| Literature DB >> 25043976 |
Ana Claudia Carreira1, Gutemberg Gomes Alves2, William Fernando Zambuzzi3, Mari Cleide Sogayar4, José Mauro Granjeiro5.
Abstract
Bone Morphogenetic Proteins (BMPs) are multifunctional secreted cytokines, which belong to the TGF-β superfamily. These glycoproteins act as a disulfide-linked homo- or heterodimers, being potent regulators of bone and cartilage formation and repair, cell proliferation during embryonic development and bone homeostasis in the adult. BMPs are promising molecules for tissue engineering and bone therapy. The present review discusses this family of proteins, their structure and biological function, their therapeutic applications and drawbacks, their effects on mesenchymal stem cells differentiation, and the cell signaling pathways involved in this process.Entities:
Keywords: Bone Morphogenetic Proteins; Bone repair; Extracellular matrix; Osteogenesis inducing proteins; Peptide growth factors; Tissue engineering
Mesh：
Substances：
Year: 2014 PMID： 25043976 DOI： 10.1016/j.abb.2014.07.011
Source DB: PubMed Journal: Arch Biochem Biophys ISSN： 0003-9861 Impact factor: 4.013