Literature DB >> 25042818

Genetic association signal near NTN4 in Tourette syndrome.

Peristera Paschou1, Dongmei Yu, Gloria Gerber, Patrick Evans, Fotis Tsetsos, Lea K Davis, Iordanis Karagiannidis, Jonathan Chaponis, Eric Gamazon, Kirsten Mueller-Vahl, Manfred Stuhrmann, Monika Schloegelhofer, Mara Stamenkovic, Johannes Hebebrand, Markus Noethen, Peter Nagy, Csaba Barta, Zsanett Tarnok, Renata Rizzo, Christel Depienne, Yulia Worbe, Andreas Hartmann, Danielle C Cath, Cathy L Budman, Paul Sandor, Cathy Barr, Thomas Wolanczyk, Harvey Singer, I-Ching Chou, Marco Grados, Danielle Posthuma, Guy A Rouleau, Harald Aschauer, Nelson B Freimer, David L Pauls, Nancy J Cox, Carol A Mathews, Jeremiah M Scharf.   

Abstract

Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10(-4) ) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10(-7) ). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles.
© 2014 American Neurological Association.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25042818      PMCID： PMC4140987          DOI： 10.1002/ana.24215

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  22 in total

1.  Sequence variants in SLITRK1 are associated with Tourette's syndrome.

Authors:  Jesse F Abelson; Kenneth Y Kwan; Brian J O'Roak; Danielle Y Baek; Althea A Stillman; Thomas M Morgan; Carol A Mathews; David L Pauls; Mladen-Roko Rasin; Murat Gunel; Nicole R Davis; A Gulhan Ercan-Sencicek; Danielle H Guez; John A Spertus; James F Leckman; Leon S Dure; Roger Kurlan; Harvey S Singer; Donald L Gilbert; Anita Farhi; Angeliki Louvi; Richard P Lifton; Nenad Sestan; Matthew W State
Journal:  Science       Date:  2005-10-14       Impact factor: 47.728

2.  Principal components analysis corrects for stratification in genome-wide association studies.

Authors:  Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich
Journal:  Nat Genet       Date:  2006-07-23       Impact factor: 38.330

3.  PLINK: a tool set for whole-genome association and population-based linkage analyses.

Authors:  Shaun Purcell; Benjamin Neale; Kathe Todd-Brown; Lori Thomas; Manuel A R Ferreira; David Bender; Julian Maller; Pamela Sklar; Paul I W de Bakker; Mark J Daly; Pak C Sham
Journal:  Am J Hum Genet       Date:  2007-07-25       Impact factor: 11.025

4.  Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?

Authors:  Steven C Elbein; Eric R Gamazon; Swapan K Das; Neda Rasouli; Philip A Kern; Nancy J Cox
Journal:  Am J Hum Genet       Date:  2012-09-07       Impact factor: 11.025

5.  Systematic localization of common disease-associated variation in regulatory DNA.

Authors:  Matthew T Maurano; Richard Humbert; Eric Rynes; Robert E Thurman; Eric Haugen; Hao Wang; Alex P Reynolds; Richard Sandstrom; Hongzhu Qu; Jennifer Brody; Anthony Shafer; Fidencio Neri; Kristen Lee; Tanya Kutyavin; Sandra Stehling-Sun; Audra K Johnson; Theresa K Canfield; Erika Giste; Morgan Diegel; Daniel Bates; R Scott Hansen; Shane Neph; Peter J Sabo; Shelly Heimfeld; Antony Raubitschek; Steven Ziegler; Chris Cotsapas; Nona Sotoodehnia; Ian Glass; Shamil R Sunyaev; Rajinder Kaul; John A Stamatoyannopoulos
Journal:  Science       Date:  2012-09-05       Impact factor: 47.728

6.  Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice.

Authors:  Kyle A Williams; Jean-Dominique Gallezot; Vladimir Pogorelov; Lissandra Castellan Baldan; Maximiliano Rapanelli; Michael Crowley; George M Anderson; Erin Loring; Roxanne Gorczyca; Eileen Billingslea; Suzanne Wasylink; Kaitlyn E Panza; A Gulhan Ercan-Sencicek; Kuakarun Krusong; Bennett L Leventhal; Hiroshi Ohtsu; Michael H Bloch; Zoë A Hughes; John H Krystal; Linda Mayes; Ivan de Araujo; Yu-Shin Ding; Matthew W State; Christopher Pittenger
Journal:  Neuron       Date:  2014-01-08       Impact factor: 17.173

7.  Support of the histaminergic hypothesis in Tourette syndrome: association of the histamine decarboxylase gene in a large sample of families.

Authors:  Iordanis Karagiannidis; Sandra Dehning; Paul Sandor; Zsanett Tarnok; Renata Rizzo; Tomasz Wolanczyk; Marcos Madruga-Garrido; Johannes Hebebrand; Markus M Nöthen; Gerd Lehmkuhl; Luca Farkas; Peter Nagy; Urszula Szymanska; Zachos Anastasiou; Vasileios Stathias; Christos Androutsos; Vaia Tsironi; Anastasia Koumoula; Csaba Barta; Peter Zill; Pablo Mir; Norbert Müller; Cathy Barr; Peristera Paschou
Journal:  J Med Genet       Date:  2013-07-03       Impact factor: 6.318

8.  Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.

Authors:  Lea K Davis; Dongmei Yu; Clare L Keenan; Eric R Gamazon; Anuar I Konkashbaev; Eske M Derks; Benjamin M Neale; Jian Yang; S Hong Lee; Patrick Evans; Cathy L Barr; Laura Bellodi; Fortu Benarroch; Gabriel Bedoya Berrio; Oscar J Bienvenu; Michael H Bloch; Rianne M Blom; Ruth D Bruun; Cathy L Budman; Beatriz Camarena; Desmond Campbell; Carolina Cappi; Julio C Cardona Silgado; Danielle C Cath; Maria C Cavallini; Denise A Chavira; Sylvain Chouinard; David V Conti; Edwin H Cook; Vladimir Coric; Bernadette A Cullen; Dieter Deforce; Richard Delorme; Yves Dion; Christopher K Edlund; Karin Egberts; Peter Falkai; Thomas V Fernandez; Patience J Gallagher; Helena Garrido; Daniel Geller; Simon L Girard; Hans J Grabe; Marco A Grados; Benjamin D Greenberg; Varda Gross-Tsur; Stephen Haddad; Gary A Heiman; Sian M J Hemmings; Ana G Hounie; Cornelia Illmann; Joseph Jankovic; Michael A Jenike; James L Kennedy; Robert A King; Barbara Kremeyer; Roger Kurlan; Nuria Lanzagorta; Marion Leboyer; James F Leckman; Leonhard Lennertz; Chunyu Liu; Christine Lochner; Thomas L Lowe; Fabio Macciardi; James T McCracken; Lauren M McGrath; Sandra C Mesa Restrepo; Rainald Moessner; Jubel Morgan; Heike Muller; Dennis L Murphy; Allan L Naarden; William Cornejo Ochoa; Roel A Ophoff; Lisa Osiecki; Andrew J Pakstis; Michele T Pato; Carlos N Pato; John Piacentini; Christopher Pittenger; Yehuda Pollak; Scott L Rauch; Tobias J Renner; Victor I Reus; Margaret A Richter; Mark A Riddle; Mary M Robertson; Roxana Romero; Maria C Rosàrio; David Rosenberg; Guy A Rouleau; Stephan Ruhrmann; Andres Ruiz-Linares; Aline S Sampaio; Jack Samuels; Paul Sandor; Brooke Sheppard; Harvey S Singer; Jan H Smit; Dan J Stein; E Strengman; Jay A Tischfield; Ana V Valencia Duarte; Homero Vallada; Filip Van Nieuwerburgh; Jeremy Veenstra-Vanderweele; Susanne Walitza; Ying Wang; Jens R Wendland; Herman G M Westenberg; Yin Yao Shugart; Euripedes C Miguel; William McMahon; Michael Wagner; Humberto Nicolini; Danielle Posthuma; Gregory L Hanna; Peter Heutink; Damiaan Denys; Paul D Arnold; Ben A Oostra; Gerald Nestadt; Nelson B Freimer; David L Pauls; Naomi R Wray; S Evelyn Stewart; Carol A Mathews; James A Knowles; Nancy J Cox; Jeremiah M Scharf
Journal:  PLoS Genet       Date:  2013-10-24       Impact factor: 5.917

9.  snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions.

Authors:  H Hermann; P Fabrizio; V A Raker; K Foulaki; H Hornig; H Brahms; R Lührmann
Journal:  EMBO J       Date:  1995-05-01       Impact factor: 11.598

10.  Genome-wide association study of Tourette's syndrome.

Authors:  J M Scharf; D Yu; C A Mathews; B M Neale; S E Stewart; J A Fagerness; P Evans; E Gamazon; C K Edlund; S K Service; A Tikhomirov; L Osiecki; C Illmann; A Pluzhnikov; A Konkashbaev; L K Davis; B Han; J Crane; P Moorjani; A T Crenshaw; M A Parkin; V I Reus; T L Lowe; M Rangel-Lugo; S Chouinard; Y Dion; S Girard; D C Cath; J H Smit; R A King; T V Fernandez; J F Leckman; K K Kidd; J R Kidd; A J Pakstis; M W State; L D Herrera; R Romero; E Fournier; P Sandor; C L Barr; N Phan; V Gross-Tsur; F Benarroch; Y Pollak; C L Budman; R D Bruun; G Erenberg; A L Naarden; P C Lee; N Weiss; B Kremeyer; G B Berrío; D D Campbell; J C Cardona Silgado; W C Ochoa; S C Mesa Restrepo; H Muller; A V Valencia Duarte; G J Lyon; M Leppert; J Morgan; R Weiss; M A Grados; K Anderson; S Davarya; H Singer; J Walkup; J Jankovic; J A Tischfield; G A Heiman; D L Gilbert; P J Hoekstra; M M Robertson; R Kurlan; C Liu; J R Gibbs; A Singleton; J Hardy; E Strengman; R A Ophoff; M Wagner; R Moessner; D B Mirel; D Posthuma; C Sabatti; E Eskin; D V Conti; J A Knowles; A Ruiz-Linares; G A Rouleau; S Purcell; P Heutink; B A Oostra; W M McMahon; N B Freimer; N J Cox; D L Pauls
Journal:  Mol Psychiatry       Date:  2012-08-14       Impact factor: 15.992
View more
  20 in total

1.  GDNF gene is associated with tourette syndrome in a family study.

Authors:  Ismael Huertas-Fernández; Pilar Gómez-Garre; Marcos Madruga-Garrido; Inmaculada Bernal-Bernal; Marta Bonilla-Toribio; Juan Francisco Martín-Rodríguez; María Teresa Cáceres-Redondo; Laura Vargas-González; Fátima Carrillo; Alberto Pascual; Jay A Tischfield; Robert A King; Gary A Heiman; Pablo Mir
Journal:  Mov Disord       Date:  2015-06-12       Impact factor: 10.338

Review 2.  Genetic Approaches to Understanding Psychiatric Disease.

Authors:  Jacob J Michaelson
Journal:  Neurotherapeutics       Date:  2017-07       Impact factor: 7.620

3.  Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome.

Authors:  Alden Y Huang; Dongmei Yu; Lea K Davis; Jae Hoon Sul; Fotis Tsetsos; Vasily Ramensky; Ivette Zelaya; Eliana Marisa Ramos; Lisa Osiecki; Jason A Chen; Lauren M McGrath; Cornelia Illmann; Paul Sandor; Cathy L Barr; Marco Grados; Harvey S Singer; Markus M Nöthen; Johannes Hebebrand; Robert A King; Yves Dion; Guy Rouleau; Cathy L Budman; Christel Depienne; Yulia Worbe; Andreas Hartmann; Kirsten R Müller-Vahl; Manfred Stuhrmann; Harald Aschauer; Mara Stamenkovic; Monika Schloegelhofer; Anastasios Konstantinidis; Gholson J Lyon; William M McMahon; Csaba Barta; Zsanett Tarnok; Peter Nagy; James R Batterson; Renata Rizzo; Danielle C Cath; Tomasz Wolanczyk; Cheston Berlin; Irene A Malaty; Michael S Okun; Douglas W Woods; Elliott Rees; Carlos N Pato; Michele T Pato; James A Knowles; Danielle Posthuma; David L Pauls; Nancy J Cox; Benjamin M Neale; Nelson B Freimer; Peristera Paschou; Carol A Mathews; Jeremiah M Scharf; Giovanni Coppola
Journal:  Neuron       Date:  2017-06-21       Impact factor: 17.173

Review 4.  Tourette syndrome: a disorder of the social decision-making network.

Authors:  Roger L Albin
Journal:  Brain       Date:  2018-02-01       Impact factor: 13.501

5.  Tourette Syndrome: Bridging the Gap between Genetics and Biology.

Authors:  Petra Richer; Thomas V Fernandez
Journal:  Mol Neuropsychiatry       Date:  2015-09-04

6.  Tourette Syndrome research highlights 2014.

Authors:  Cheryl A Richards; Kevin J Black
Journal:  F1000Res       Date:  2015-03-16

7.  The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery.

Authors:  Marianthi Georgitsi; A Jeremy Willsey; Carol A Mathews; Matthew State; Jeremiah M Scharf; Peristera Paschou
Journal:  Front Neurosci       Date:  2016-08-03       Impact factor: 4.677

8.  Meta-Analysis of Tourette Syndrome and Attention Deficit Hyperactivity Disorder Provides Support for a Shared Genetic Basis.

Authors:  Fotis Tsetsos; Shanmukha S Padmanabhuni; John Alexander; Iordanis Karagiannidis; Margaritis Tsifintaris; Apostolia Topaloudi; Dimitrios Mantzaris; Marianthi Georgitsi; Petros Drineas; Peristera Paschou
Journal:  Front Neurosci       Date:  2016-07-22       Impact factor: 4.677

Review 9.  Recent Advances in Understanding and Managing Tourette Syndrome.

Authors:  Mary Ann Thenganatt; Joseph Jankovic
Journal:  F1000Res       Date:  2016-02-09

Review 10.  From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research.

Authors:  Luca Pagliaroli; Borbála Vető; Tamás Arányi; Csaba Barta
Journal:  Front Neurosci       Date:  2016-07-12       Impact factor: 4.677
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.