Literature DB >> 2504273

Recombinant interferon-gamma induces HLA-DR expression on human corneal epithelial and endothelial cells in vitro: a preliminary report.

A M el-Asrar1, J J van den Oord, A Billiau, V Desmet, M h Emarah, L Missotten.   

Abstract

The effect of interferon-gamma on the expression in situ of major histocompatibility complex (MHC) products in human corneas was studied in vitro. Incubation for four days with 5 or 50 mg/l of Escherichia coli-derived recombinant human interferon-gamma resulted in the appearance de novo of MHC class II or HLA-DR antigens on variable numbers of corneal epithelial cells as well as on corneal endothelium, whereas it had no effect on the expression of MHC class I or HLA-ABC antigens. These results may help to explain the mechanism underlying the expression of HLA-DR antigens on corneal and limbal epithelium in various inflammatory eye diseases.

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Year:  1989        PMID： 2504273      PMCID： PMC1041822          DOI： 10.1136/bjo.73.8.587

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  21 in total

1.  Immunopathology of trachomatous conjunctivitis.

Authors:  A M el-Asrar; J J Van den Oord; K Geboes; L Missotten; M H Emarah; V Desmet
Journal:  Br J Ophthalmol       Date:  1989-04       Impact factor: 4.638

2.  Expression of Ia antigen-like molecules on cells in the corneal epithelium.

Authors:  L Klareskog; U Forsum; U M Tjernlund; L Rask; P A Peterson
Journal:  Invest Ophthalmol Vis Sci       Date:  1979-03       Impact factor: 4.799

3.  Human cytotoxic T cell clones directed at autologous virus-transformed targets: further evidence for linkage of genetic restriction to T4 and T8 surface glycoproteins.

Authors:  S C Meuer; J C Hodgdon; D A Cooper; R E Hussey; K A Fitzgerald; S F Schlossman; E L Reinherz
Journal:  J Immunol       Date:  1983-07       Impact factor: 5.422

4.  Two populations of Ia-like molecules on a human B cell line.

Authors:  L A Lampson; R Levy
Journal:  J Immunol       Date:  1980-07       Impact factor: 5.422

Review 5.  The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages.

Authors:  E R Unanue
Journal:  Adv Immunol       Date:  1981       Impact factor: 3.543

6.  Detection of HLA class I and II antigens in rejected human corneal allografts.

Authors:  J S Pepose; K M Gardner; M S Nestor; R Y Foos; T H Pettit
Journal:  Ophthalmology       Date:  1985-11       Impact factor: 12.079

7.  Human corneal endothelium in organ culture. The influence of temperature and medium of incubation.

Authors:  S Sperling
Journal:  Acta Ophthalmol (Copenh)       Date:  1979-04

8.  Immunology of corneal allograft rejection: HLA-DR antigens on human corneal cells.

Authors:  E Young; W J Stark; R A Prendergast
Journal:  Invest Ophthalmol Vis Sci       Date:  1985-04       Impact factor: 4.799

9.  Langerhans cells of the ocular surface.

Authors:  T E Gillette; J W Chandler; J V Greiner
Journal:  Ophthalmology       Date:  1982-06       Impact factor: 12.079

10.  Beneficial effects of histocompatibility in high-risk corneal transplantation.

Authors:  G N Foulks; F Sanfilippo
Journal:  Am J Ophthalmol       Date:  1982-11       Impact factor: 5.258
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  7 in total

Review 1.  Concise review: immunological properties of ocular surface and importance of limbal stem cells for transplantation.

Authors:  Bakiah Shaharuddin; Sajjad Ahmad; Annette Meeson; Simi Ali
Journal:  Stem Cells Transl Med       Date:  2013-07-01       Impact factor: 6.940

2.  Antigen presentation of herpes simplex virus by corneal epithelium--an in vitro and in vivo study.

Authors:  G T Fahy; D C Hooper; D L Easty
Journal:  Br J Ophthalmol       Date:  1993-07       Impact factor: 4.638

3.  Adhesion molecules in vernal keratoconjunctivitis.

Authors:  A M Abu el-Asrar; K Geboes; S al-Kharashi; K F Tabbara; L Missotten; V Desmet
Journal:  Br J Ophthalmol       Date:  1997-12       Impact factor: 4.638

4.  Intercellular adhesion molecule-1 in human corneal endothelium. Modulation and function.

Authors:  V M Elner; S G Elner; M A Pavilack; R F Todd; B Y Yue; A R Huber
Journal:  Am J Pathol       Date:  1991-03       Impact factor: 4.307

5.  Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.

Authors:  A M el-Asrar; D Maimone; P H Morse; C Lascola; A T Reder
Journal:  Br J Ophthalmol       Date:  1991-08       Impact factor: 4.638

6.  Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II.

Authors:  Derek J Royer; Michael H Elliott; Yun Z Le; Daniel J J Carr
Journal:  Invest Ophthalmol Vis Sci       Date:  2018-03-01       Impact factor: 4.799

7.  Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome.

Authors:  Zhen Meng; Wannita Klinngam; Maria C Edman; Sarah F Hamm-Alvarez
Journal:  PLoS One       Date:  2017-09-13       Impact factor: 3.240
  7 in total

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