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Literature DB >> 25042716

ENU Mutagenesis in the Mouse.

Abstract

This unit describes the treatment of laboratory mice with the mutagen N-ethyl-N-nitrosourea (ENU) to induce very highly increased rates of mutation throughout the genome. Further, it describes several popular mating schemes designed to produce animals displaying phenotypes associated with the induced mutations.

Entities: Chemical Disease Gene Species

Keywords: alkylating agent; genome sequencing; per locus mutation frequency; phenotype-driven mutagenesis; spermatogonial stem cells

Mesh：

Substances：
Ethylnitrosourea

Year: 2014 PMID： 25042716 PMCID： PMC4113905 DOI： 10.1002/0471142905.hg1504s82

Source DB: PubMed Journal: Curr Protoc Hum Genet ISSN： 1934-8258

39 in total

1. Effective chemical mutagenesis in FVB/N mice requires low doses of ethylnitrosourea.

Authors: A P Davis; R P Woychik; M J Justice
Journal: Mamm Genome Date: 1999-03 Impact factor: 2.957

2. A mouse for all reasons.

Authors: Francis S Collins; Janet Rossant; Wolfgang Wurst
Journal: Cell Date: 2007-01-12 Impact factor: 41.582

Review 3. Forward genetic analysis of TLR-signaling pathways: an evaluation.

Authors: Kasper Hoebe; Bruce Beutler
Journal: Adv Drug Deliv Rev Date: 2008-02-15 Impact factor: 15.470

4. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

Authors: Adam J Dupuy; Keiko Akagi; David A Largaespada; Neal G Copeland; Nancy A Jenkins
Journal: Nature Date: 2005-07-14 Impact factor: 49.962

5. Molecular characterization of ENU mouse mutagenesis and archives.

Authors: Yoshiyuki Sakuraba; Hideki Sezutsu; K Ryo Takahasi; Keiko Tsuchihashi; Rie Ichikawa; Naomi Fujimoto; Satoko Kaneko; Yuji Nakai; Masashi Uchiyama; Noriko Goda; Rika Motoi; Ami Ikeda; Yuko Karashima; Maki Inoue; Hideki Kaneda; Hiroshi Masuya; Osamu Minowa; Hideki Noguchi; Atsushi Toyoda; Yoshiyuki Sakaki; Shigeharu Wakana; Tetsuo Noda; Toshihiko Shiroishi; Yoichi Gondo
Journal: Biochem Biophys Res Commun Date: 2005-10-21 Impact factor: 3.575

6. Cilia and Hedgehog responsiveness in the mouse.

Authors: Danwei Huangfu; Kathryn V Anderson
Journal: Proc Natl Acad Sci U S A Date: 2005-08-01 Impact factor: 11.205

7. Mouse models of human phenylketonuria.

Authors: A Shedlovsky; J D McDonald; D Symula; W F Dove
Journal: Genetics Date: 1993-08 Impact factor: 4.562

8. A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.

Authors: Ivana Matera; Dawn E Watkins-Chow; Stacie K Loftus; Ling Hou; Arturo Incao; Debra L Silver; Cecelia Rivas; Eugene C Elliott; Laura L Baxter; William J Pavan
Journal: Hum Mol Genet Date: 2008-04-07 Impact factor: 6.150

Review 9. DNA damage and repair in somatic and germ cells in vivo.

Authors: E W Vogel; A T Natarajan
Journal: Mutat Res Date: 1995-08 Impact factor: 2.433

10. Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.

Authors: Jennifer L Moran; Andrew D Bolton; Pamela V Tran; Alison Brown; Noelle D Dwyer; Danielle K Manning; Bryan C Bjork; Cheng Li; Kate Montgomery; Sandra M Siepka; Martha Hotz Vitaterna; Joseph S Takahashi; Tim Wiltshire; David J Kwiatkowski; Raju Kucherlapati; David R Beier
Journal: Genome Res Date: 2006-02-03 Impact factor: 9.043

9 in total

1. Improvement in Double Staining With Fluoro-Jade C and Fluorescent Immunostaining: FJC Staining Is Not Specific to Degenerating Mature Neurons.

Authors: Takuya Ikenari; Tatsuya Kawaguchi; Rei Ota; Miki Matsui; Ryota Yoshida; Tetsuji Mori
Journal: J Histochem Cytochem Date: 2021-08-31 Impact factor: 4.137

Review 2. Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis.

Authors: Francesca De Giorgio; Cheryl Maduro; Elizabeth M C Fisher; Abraham Acevedo-Arozena
Journal: Dis Model Mech Date: 2019-01-02 Impact factor: 5.758

ENU Mutagenesis in the Mouse.

1. Effective chemical mutagenesis in FVB/N mice requires low doses of ethylnitrosourea.

2. A mouse for all reasons.

Review 3. Forward genetic analysis of TLR-signaling pathways: an evaluation.

4. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

5. Molecular characterization of ENU mouse mutagenesis and archives.

6. Cilia and Hedgehog responsiveness in the mouse.

7. Mouse models of human phenylketonuria.

8. A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.

Review 9. DNA damage and repair in somatic and germ cells in vivo.

10. Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.

1. Improvement in Double Staining With Fluoro-Jade C and Fluorescent Immunostaining: FJC Staining Is Not Specific to Degenerating Mature Neurons.

Review 2. Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis.

Review 3. Defining new genetic etiologies of male infertility: progress and future prospects.

4. Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice.

5. Differential requirements of tubulin genes in mammalian forebrain development.

6. Machine Learning Techniques for Classifying the Mutagenic Origins of Point Mutations.

Review 7. Mouse models for muscular dystrophies: an overview.

Review 8. Tissue-Nonspecific Alkaline Phosphatase, a Possible Mediator of Cell Maturation: Towards a New Paradigm.

9. A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression.