OBJECTIVES/HYPOTHESIS: The incidence of human papillomavirus (HPV)-driven disease beyond the oropharynx varies greatly in the reported literature. STUDY DESIGN: Case series. METHODS: Two hundred twenty-one samples were strictly classified to the subsites of oral cavity, larynx, or hypopharynx at the time of primary surgery. Formalin-fixed paraffin-embedded samples were subjected to a validated, tiered, diagnostic algorithm of p16 immunohistochemistry, high-risk HPV in situ hybridization, and quantitative polymerase chain reaction for HPV E6 DNA. An additional 60 oropharyngeal cases acted as an internal biological control. RESULTS: An incidence of 4% of HPV-driven cases was observed across the subsites outside the oropharynx compared to 70% of tumors confined within it. CONCLUSIONS: This is the first reporting of a broad range of nonoropharyngeal HPV rates using this validated diagnostic algorithm. It remains unclear whether patients with HPV-driven disease originating outside the oropharynx enjoy the same survival advantage apparent in those patients with oropharyngeal squamous cell carcinomas. LEVEL OF EVIDENCE: 4 Laryngoscope, 124:2739-2744, 2014.
OBJECTIVES/HYPOTHESIS: The incidence of human papillomavirus (HPV)-driven disease beyond the oropharynx varies greatly in the reported literature. STUDY DESIGN: Case series. METHODS: Two hundred twenty-one samples were strictly classified to the subsites of oral cavity, larynx, or hypopharynx at the time of primary surgery. Formalin-fixed paraffin-embedded samples were subjected to a validated, tiered, diagnostic algorithm of p16 immunohistochemistry, high-risk HPV in situ hybridization, and quantitative polymerase chain reaction for HPV E6 DNA. An additional 60 oropharyngeal cases acted as an internal biological control. RESULTS: An incidence of 4% of HPV-driven cases was observed across the subsites outside the oropharynx compared to 70% of tumors confined within it. CONCLUSIONS: This is the first reporting of a broad range of nonoropharyngeal HPV rates using this validated diagnostic algorithm. It remains unclear whether patients with HPV-driven disease originating outside the oropharynx enjoy the same survival advantage apparent in those patients with oropharyngeal squamous cell carcinomas. LEVEL OF EVIDENCE: 4 Laryngoscope, 124:2739-2744, 2014.
Authors: Mark E Zafereo; Li Xu; Kristina R Dahlstrom; Carlo A Viamonte; Adel K El-Naggar; Qingyi Wei; Guojun Li; Erich M Sturgis Journal: Oral Oncol Date: 2016-03-21 Impact factor: 5.337
Authors: Annekatrin Coordes; Klaus Lenz; Xu Qian; Minoo Lenarz; Andreas M Kaufmann; Andreas E Albers Journal: Eur Arch Otorhinolaryngol Date: 2015-07-31 Impact factor: 2.503
Authors: Stephanie G Craig; Lesley A Anderson; Michael Moran; Laura Graham; Keith Currie; Keith Rooney; Max Robinson; Victoria Bingham; Kate S Cuschieri; Stephen McQuaid; Andrew G Schache; Terry M Jones; Dennis McCance; Manuel Salto-Tellez; Simon S McDade; Jacqueline A James Journal: Cancer Epidemiol Biomarkers Prev Date: 2019-10-30 Impact factor: 4.090
Authors: Andrew G Schache; Ned G Powell; Kate S Cuschieri; Max Robinson; Sam Leary; Hisham Mehanna; Davy Rapozo; Anna Long; Heather Cubie; Elizabeth Junor; Hannah Monaghan; Kevin J Harrington; Christopher M Nutting; Ulrike Schick; Andy S Lau; Navdeep Upile; Jon Sheard; Kath Brougham; Catharine M L West; Ken Oguejiofor; Steve Thomas; Andy R Ness; Miranda Pring; Gareth J Thomas; Emma V King; Dennis J McCance; Jacqueline A James; Michael Moran; Phil Sloan; Richard J Shaw; Mererid Evans; Terry M Jones Journal: Cancer Res Date: 2016-08-28 Impact factor: 13.312