Literature DB >> 2504171

Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid arthritis.

G W Cannon1, S H Pincus, R D Emkey, A Denes, S A Cohen, F Wolfe, P A Saway, A M Jaffer, A L Weaver, L Cogen.   

Abstract

One hundred five patients were enrolled in a 12-week, randomized, prospective, double-blind, placebo-controlled trial of recombinant human gamma-interferon (rHu gamma-IFN) for the treatment of rheumatoid arthritis. Fifty-four patients received rHu gamma-IFN and 51 received placebo. Forty-two patients in each group completed the 12-week trial. Some clinical improvement occurred in both groups of patients. Although the improvement with rHu gamma-IFN was greater than that with placebo, the differences were generally not statistically significant.

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Year:  1989        PMID: 2504171     DOI: 10.1002/anr.1780320805

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN: 0004-3591


  29 in total

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Review 10.  The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid arthritis.

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